Effective resistance exercise method for muscle atrophy based on a cell biology

基于细胞生物学的治疗肌肉萎缩的有效抗阻运动方法

• 批准号: 22700555
• 负责人: ITOH Yuta
• 金额: $ 2.16万
• 依托单位: Nagoya Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700555/
• 关键词: 筋萎縮; 筋力増強運動; 細胞生物学; リハビリテーション科学; 運動療法学; 動物; 骨・筋肉; 筋肉生理学; リハビリテーション; 生理学; 細胞・組織; マウス

Recovery from skeletal muscle atrophy by resistance exercise was examined in mice. After tail suspention, the animals were subjected to resistance exercise(RE). The myofiber thickness of soleus muscle of the mice with RE was significantly greater than that of non RE group, and was not significantly different from normal mice. Intriguingly, the number of myonuclei of the mice with RE was 1.5 times greater than that of non RE mice. We found that the newly-acquired myonuclei were increased within a few days after the onset of RE, suggesting that satellite cells proliferated rapidly after the onset of RE and fused to the myofibers.

在小鼠中检查通过阻力运动从骨骼肌萎缩的恢复。尾部悬吊后，动物进行抗阻运动（RE）。RE组小鼠比目鱼肌肌纤维厚度显著大于非RE组，与正常小鼠无显著差异。有趣的是，RE小鼠的肌核数量是非RE小鼠的1.5倍。我们发现，新获得的肌细胞核在RE发病后几天内增加，表明卫星细胞在RE发病后迅速增殖并融合到肌纤维。

项目成果

筋力増強運動の期間が萎縮筋 の筋線維の太さや数、筋核数に与える影響

强肌运动持续时间对萎缩肌肌纤维粗细、数量及肌核数量的影响

• 发表时间: 2011
• 作者: Kanazashi M;Okumura Y;Al-Nassan S;Murakami S;Kondo H;Nagatomo F; Fujita N;Ishihara A;Roy RR;Fujino H;佐々木健史，長峯隆，松山清治;伊東佑太・縣信秀・宮津真寿美・平野孝 行・河上敬介.
• 通讯作者: 伊東佑太・縣信秀・宮津真寿美・平野孝 行・河上敬介.

Effect of resistance exercise on the recovery of atrophied muscles in mice

抗阻运动对小鼠萎缩肌肉恢复的影响

• 发表时间: 2011
• 作者: Onishi H;Oyama M;Soma T,Sugawara K;Kirimoto H;Murakami H,Kameyama S;大西秀明,大山峰生,相馬俊雄,菅原和広,村上淳博,亀山茂樹;大山峰生,大西秀明,相馬俊雄,桐本光,亀山茂樹;大山峰生,大西秀明,相馬俊雄,桐本光,亀山茂樹;菅原和広,大西秀明,相馬俊雄,大山峰生,村上博淳,亀山茂樹;田辺茂雄;Yuta Itoh;伊東佑太・縣信秀・宮津真寿美・平野孝行・河上敬介;伊東佑太;Yuta Itoh・Nobuhide Agata・Masumi Miyazu・Takayuki Hirano・Keisuke Kawakami;Yuta Itoh・Nobuhide Agata・Masumi Miyazu・Masahiro Sokabe・Keisuke Kawakami
• 通讯作者: Yuta Itoh・Nobuhide Agata・Masumi Miyazu・Masahiro Sokabe・Keisuke Kawakami

Myonuclei increase through resistance exercises on mouse skeletal muscle that underwent muscle atrophy

通过对经历肌肉萎缩的小鼠骨骼肌进行阻力训练，肌核增加

• 作者: Itoh Y.;Agata N.;Inoue-Miyazu M.;Hirano T.;Kawakami K.
• 通讯作者: Kawakami K.

萎縮筋に対する負荷運動は、筋核を増加させる

萎缩肌肉的负荷运动会增加肌核

• 发表时间: 2010
• 作者: Suda C;Kanazawa M;Yao Q;Takashima K;Muroya Y;Mori N;Nagasaka M;Ito O;Kurosawa H;Kohzuki M.;Emoto M;伊東佑太
• 通讯作者: 伊東佑太