Study of novel lipid-lowering effects of sesaminol, a sesame lignan

芝麻木脂素芝麻素酚的新型降脂作用研究

• 批准号: 22700752
• 负责人: NISHIZONO Shoko
• 金额: $ 2.58万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700752/
• 关键词: ゴマリグナン; セサミノールアグリコン; 脂質代謝; ラット; 栄養学; 食品; 脂質; 植物; 農林水産品; 脂質代謝調節; セサミノール; トリグリセリド濃度; コレステロール濃度

Sesaminol is a sesame lignin and is present most exclusively occurring as sesaminol triglucoside in sesame seed. In this study, effect of sesaminol aglycone on lipid metabolism was investigated in Sprague-Dawley rats. Four-week-old male rats were fed diets containing 0～ 0. 20% sesaminol. After 4 week-feeding period, serum and liver lipids levels were determined. We reported, for the first time, that dietary sesaminol significantly reduce(s) serum and hepatic lipids, especially triglyceride levels in a dose dependent manner ; this reduction appeared to be greater than those of a well-known other functional components. The mechanism responsible for the observed reduction in the concentration of triglyceride may be due to a reciprocal response in the enzyme activities involved in fatty acid synthesis and oxidation.

芝麻氨基醇是一种芝麻木质素，在芝麻中以芝麻氨基三糖苷的形式存在。本研究探讨了芝麻氨基苷元对Sprague-Dawley大鼠脂质代谢的影响。4周龄雄性大鼠饲喂含0~ 0。sesaminol 20%。饲喂4周后，测定血清和肝脏脂质水平。我们首次报道，膳食芝麻胺可显著降低血清和肝脏脂质，尤其是甘油三酯水平，且呈剂量依赖性；这种减少似乎比众所周知的其他功能成分更大。所观察到的甘油三酯浓度降低的机制可能是由于脂肪酸合成和氧化所涉及的酶活性的相互反应。