Study of novel lipid-lowering effects of sesaminol, a sesame lignan

芝麻酚是一种芝麻木质素，在芝麻种子中主要以芝麻酚三葡糖苷的形式存在。本研究观察了芝麻氨基苷元对SD大鼠脂代谢的影响。4周龄雄性大鼠饲喂含0~0的饲料。20%芝麻酚。喂养4周后，检测血清和肝脂水平。我们首次报道，膳食芝麻酚显著降低(S)血清和肝脏脂质水平，尤其是甘油三酯水平，并呈剂量依赖关系；这种降低似乎比众所周知的其他功能成分更大。甘油三酯浓度降低的机制可能是由于参与脂肪酸合成和氧化的酶活性的相互反应。

Sesaminol is a sesame lignin and is present most exclusively occurring as sesaminol triglucoside in sesame seed. In this study, effect of sesaminol aglycone on lipid metabolism was investigated in Sprague-Dawley rats. Four-week-old male rats were fed diets containing 0～ 0. 20% sesaminol. After 4 week-feeding period, serum and liver lipids levels were determined. We reported, for the first time, that dietary sesaminol significantly reduce(s) serum and hepatic lipids, especially triglyceride levels in a dose dependent manner ; this reduction appeared to be greater than those of a well-known other functional components. The mechanism responsible for the observed reduction in the concentration of triglyceride may be due to a reciprocal response in the enzyme activities involved in fatty acid synthesis and oxidation.