Identification of "cancer stem cell" of mature lymphoid malignancy

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For a search and the identification of malignant lymphoma stem cells, we made the malignant lymphoma model with the NOG mouse using patient samples. The tumor cells of the mantle cell lymphoma invaded the systemic organ including liver, spleen, bone marrow and formed a bulky mass in the abdominal cavity. The cells obtained from the tumor were available for the passage to new NOG mouse. And about the model of the angioimmunoblastic T-cell lymphoma, it was shown that all tumors of the patients and NOG mice from the first to the fourth generation were the same clones as a result of analysis. And B cells, plasma cells and the production of the gamma globulin the reactive component seen with the first generation disappeared the second generation later, and tumor cells were thought to gradually reinforce the tumorigenesity in the NOG mouse in vivo.