A cancer stem cells search and pathogenesis elucidation of AITL

癌症干细胞的寻找和AITL发病机制的阐明

• 批准号: 24700982
• 负责人: ITO Asahi
• 金额: $ 2.83万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700982/
• 关键词: AITL; NOGマウス; モデルマウス; 悪性リンパ腫; がん幹細胞

We established the AITL model mouse which transplanted fresh patient samples of AITL to the NOG mouse which was an immunodeficiency mouse. This model reflected various condition of human AITL very well. We could not observe a gamma globulin production and the growth of B lymphocyte, plasma cells reproduced with tumor cells of AITL in a process that AITL fresh tumor cells were transfused into NOG mouse and made transplantation, and only tumor cells were found to grow. In other words, as for that we could observe various pictures of AITL, a thing only the first model mouse which we transplanted was found first. Only the strong tumor cells main body of the power to engraft more in a process to make transplantation survived it, and it was thought that other part were lost.

我们将患者新鲜的AITL样本移植到免疫缺陷小鼠NOG小鼠体内，建立AITL模型小鼠。该模型很好地反映了人类AITL的各种状况。在将AITL新鲜肿瘤细胞输注到NOG小鼠体内进行移植的过程中，我们未观察到AITL的γ球蛋白的产生以及B淋巴细胞、浆细胞与肿瘤细胞的繁殖，仅发现肿瘤细胞的生长。换句话说，我们可以观察到各种各样的AITL图片，这是我们首先移植的第一只模型小鼠才发现的。只有强大的肿瘤细胞主体的移植物能力更强，在一个过程中使移植物存活下来，而另一部分则被认为丢失了。