Innovative development of antibody drug with ultrastructural in vivo imaging

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To develop antibody drug with cheap and high medicinal effect, this study aimed to visualize and analyze where and how the effect of antibody drug works in the tumor tissues using 3D imaging with high spatial accuracy. I performed fluorescence in vivo and ex vivo imaging and CT imaging, and then aimed to integrate each imaging data. I succeeded in developing new in vivo imaging system, ex vivo imaging 50μm thickness tumor tissues whose cancer cells activity were well, and CT-imaging with new slica-coating gold nano-particles. Now I am imaging tumor-bearing mice with antibody drug-conjugated fluorescent nano-particles or antibody drug-conjugated slica-coating gold nano-particles using fluorescence in vivo and ex vivo imaging or CT imaging. As the results of these, I obtained a preliminary result in the relationship between EPR effect and antibody drug effect.