Synthetic Study of Brasilicardin A, a novel immunosuppressive agent

本研究主要是化学合成一种具有广泛研究价值的新型免疫抑制剂巴西绿卡素A。因此，我们开发了一种基于γ、δ-环氧-α、β-不饱和环酮的区域和立体选择性S_N2'烷基化反应在碳环上立体选择性构建全碳季立体中心的新方法，以及（ii）一种立体选择性构建巴西木苷a的反syn-反过氢菲骨架（ABC环体系）的方法，这是全合成的最大障碍之一。

This research mainly aimed at chemical synthesis of Brasilicardin A, a novel immunosuppressive agent of broad interest. As a result, we developed(i) a new and practical method for stereoselective construction of an all-carbon quaternary stereogenic center on a carbocyclic ring based on regio-and stereoselective S_N2' alkylation reactions ofγ,δ-epoxy-α,β-unsaturated cyclic ketones, and(ii) a stereoselective method for constructing the anti-syn-anti-perhydrophenanthrene skeleton(ABC ring system) of Brasilicardin A, which represents one of the largest obstacles to the total synthesis.