Synthetic Study of Azaspiracid

阿扎匹酸是一种具有独特分子结构和立体化学复杂性的海洋毒素，在全合成的合成研究中，建立了以下关键合成方法。(1)以Oriyama的手性二胺为催化剂，通过不对称酰化反应拆分仲α-羟基锡烷，然后将未反应的醇缩醛化为MOM-醚，一锅法合成了光学活性的α-羟基锡烷衍生物。(2)利用Fe（TPP）OTf催化的顺序异构化-缩醛化反应，发展了一种新的高效的双环FG环结构的合成方法。

During the synthetic studies toward the total synthesis of Azaspiracid, a marine toxin possessing unique molecular structure with stereochemical complexity, the following key synthetic methods were established. (1) A practical synthetic method for optically active α-hydroxystannane derivatives has been developed by kinetic resolution of secondary α-hydroxystannanes via asymmetric acylation reaction by using the Oriyama's chiral diamine catalyst followed by acetalization of the unreacted alcohol as a MOM-ether in one-pot. (2) A novel and efficient synthetic method for the construction of the bicyclic FG-ring moiety has been developed by using Fe(TPP)OTf-catalyzed sequential isomerization-acetalyzation reaction.