Development of synthetic methods and functions of disubstituted hybrid calixarenes

本文综述了用配位官能团取代传统杯[4]芳烃的两个羟基的二取代杂化杯[4]芳烃的合成方法和功能的研究进展。优化了ullmann型胺化工艺，在25位和27位分别引入了磷酸酰基、磷酸基和碘基，并实现了碘基向羧基的转化。进一步阐明了二膦衍生物与金属离子的独特配位方式以及二膦酸对稀土金属离子的选择性萃取。

Development of the synthetic methods and functions of disubstituted hybrid calix[4]arenes, in which two hydroxy groups of conventional calix[4]arene are replaced with coordinative functional groups, have been examined. The optimization of Ullmann-type amination, introduction of phosphinoyl, phosphono, and iodo group at 25- and 27 positions and the conversion of iodo groups to carboxy groups were achieved. Furthermore, the elucidation of unique coordination manner of diphosphine derivative toward metal ions and the selective extraction of rare-earth metal ions by diphosphonic acid were achieved.