Design of Dual Imaging Probes for Magnetic Resonance and Luminescence via Self-assembly of Lanthanide and Thiacalixarene

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The study is aimed at a developing dual imaging probe (DIP) for magnetic resonance imaging (MRI) and luminescence imaging to enhance the sensitivity and resolution of the current imaging techniques. Here we used thiacalixarene as a clustering ligand for multi-lanthanide core enabling both magnetic relaxation and luminescence. We have successfully elucidated that the multi-nuclear complex fulfill prerequisites for DIP such as (1) formation of single species, (2) high kinetic stability, (3) relaxivity, and(4) luminescence functions.