Function of spinal neural circuit for generating muscle activities

脊髓神经回路产生肌肉活动的功能

• 批准号: 23300143
• 负责人: SEKI Kazuhiko
• 金额: $ 12.9万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300143/
• 关键词: 脊髄; 下降路; 抑制性; 霊長類; 反射; 介在ニューロン; 随意運動; 上肢; シナジー; 無麻酔; 手首運動; 抑制性ニューロン; シナプス前抑制; 筋電図

In monkeys performing precision grip task, we recorded activity from the cervical spinal cordsimultaneously with electromyographic (EMG) activity from hand and arm muscles during the task. Most PreM-INs (23/25) displayed movement-related firing rate modulations: 11 had phasic followed by tonic facilitation (p+t+); 4 were pure phasic; 4 were pure tonic; and 4 were deactivated, while their target muscles consistently had p+t+ activity (65/66 muscles). Results indicated that several neural pathway could be mediated by the spinal PreM-INs makes a significant contribution to the control of precision grip in primates. For detecting the descending signal mediated by spinal Ins, we identified 251 M1 and 90 rubrospinal neurons, and extracted muscle synergies using non-negative matrix factorization from the EMG signals. Clustering analysis of the PreM connection patterns of the populations indicate each PreM population can provide a neuronal underpinning of muscle synergies in contrasting ways.

在执行精确抓握任务的猴中，我们同时记录了颈脊髓的活动以及手和手臂肌肉的肌电图（EMG）活动。大多数PreM-IN（23/25）显示出运动相关的放电率调制：11个具有相位性，随后是强直性易化（p+t+）; 4个是纯相位性; 4个是纯强直性; 4个失活，而其靶肌肉始终具有p+t+活动（65/66肌肉）。研究结果表明，脊髓前M-INs可能介导的几种神经通路对灵长类动物精确抓握的控制做出了重要贡献。为了检测由脊髓Ins介导的下行信号，我们识别了251个M1和90个红核脊髓神经元，并使用非负矩阵分解从EMG信号中提取肌肉协同作用。群体的前M连接模式的聚类分析表明，每个前M群体可以提供一个神经元的肌肉协同作用的对比方式的基础。

项目成果

Rostrocaudal distribution of calbindin D28k positive cells in the ventral horn of the cervical spinal cord in monkeys.

猴子颈髓腹角钙结合蛋白 D28k 阳性细胞的吻尾分布。

• 发表时间: 2013
• 作者: Nishimaru H;Kakizaki M;Seki K
• 通讯作者: Seki K

Neural basis for hand muscle synergy in primate spinal cord

灵长类脊髓手部肌肉协同作用的神经基础

• 发表时间: 2011
• 作者: Takei Tomohiko;Seki Kazuhiko
• 通讯作者: Seki Kazuhiko

Classification of volleys in sensory and motor fibers of peripheral nerve evoked by intraspinal microstimulation．

椎管内微刺激引起的周围神经感觉和运动纤维的截击分类。

• 发表时间: 2012
• 作者: Kim G;Seki K
• 通讯作者: Seki K

手と指の運動は脳によってどのように制御されているか

大脑如何控制手和手指的运动

• 发表时间: 2011
• 作者: Shintani;S.;Oyama;K. Fukuda;N.;and Ishiwata;S.;関和彦
• 通讯作者: 関和彦

サル頸髄の興奮性は上肢の姿勢によって変化する

猴颈脊髓的兴奋性根据上肢的姿势而变化。

• 作者: 矢口博彬;コワルスキーデイヴィッド;武井智彦;満渕邦彦;関和彦
• 通讯作者: 関和彦