Interaction of oxygen carrier protein with mitochondria activity during muscle contraction

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Cellular respiration is influenced by a wide range of mechanisms including the response of the cardiovascular and metabolic systems to meet the changing energy demands in muscle. The present focused on myoglobin (Mb), an important cellular O2 binding protein that is expressed in skeletal and cardiac muscle cells, and set a hypothesis that Mb will have a direct interaction with the mitochondrial respiration. The present study using rodent hindlimb muscles and cultured myoblast (L6), obtained evidences that Mb directly co-localized on mitochondria within a myocytes. Unexpectedly, Mb presences in mitochondria. The mitochondrial Mb can interact with complex IV to facilitated O2 consumption in mitochondria. Further investigation must be necessary to clarify the target proteins of Mb within mitochondria to obtain the new physiological functions of the mitochondrial Mb in myocytes.