Identification of the urinary biomarker to predect hypertension in young adults

本研究旨在鉴定尿液生物标志物，以预测高血压的发病机制。我们招募了2011年在宫城县川崎镇进行过健康检查的大学新生和成年人。分析尿中血管紧张素原（AGT）、炎症标志物、氧化应激标志物、羰基化合物及血清AGT、炎症标志物水平。本研究确定了年轻肥胖成人血压与尿AGT和炎症标志物排泄之间的关系。从多元线性回归分析，尿AGT排泄与成人血压显著相关。本研究提示尿AGT排泄可预测年轻基底成人高血压的发病机制。

The present study was desiged to identify the urinary biomarker to predict the pathogenesis of hypertension. We enrolled incoming freshmen of our university and adults who have taken health checkup in Kawasaki town in Miyagi in 2011. Urinary excertion of angiotensinogen (AGT), inflammation markers, oxidative stress markers and carbonyl compounds and serum AGT, inflammation markers levels were analyzed. The present study determined the association between blood pressure and uriary AGT and inflammation markers excretion in young obese adults. From multiple linear regression analysis, urinary AGT excretion was significantly associated with blood pressure in adults.This study suggested that urinary AGT excretion would predicte the pathogenesis of hypertension inyoung obase adults.