Breathing and control of upper airway

呼吸和上呼吸道的控制

• 批准号: 61570363
• 负责人: HIDA Wataru
• 金额: $ 1.22万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570363/
• 关键词: Upper airway mechanics; upper airway muscle; electrical stimulation; 圧-気流速度曲線; 電気刺激; 筋電図; 横隔膜筋電図

To examine the correlation between control of breathing and control of upper airway, the following studies were undertaken in anesthetized dogs: 1) pressure-flow relationship were obtained during graded inspiratory loading, hyperoxic hypercapnia and normocapnic hypoxemia, 2) responses of electromyogram of posterior cricoarytenoid muscle and alae nasi to electrical stimulation of gastrocnemius were studied, and 3) effects of electrical stimulation of genioglossue muscle on upper airway resistance were studied. We found that 1) pressure-flow relationship shifted upwards with increase in inspiratory loading, hypercapnia and hypoxia, 2) response of cricoarytenoid EMG and alae nasi EMG increased repidly at onset of electrical stimulation of the intact nerve to gastrocnemius, and this response was disappeared by stimulation of peripheral cut end of the nerve to gastrocnemius, and 3) Upper airway resistance decreased with stimulation-frequency dependency, particulary repidly decreased between 20-50 Hz. These findings suggest that upper airway patency was affected by activation of respiratory controller due to neural stimule from respiratory and non-respiratory muscles and/or humoral stimuli, and tone of genioglossus muscle itself would be important to maintain upper airway patency.

为了研究呼吸控制与上呼吸道控制之间的相关性，我们对麻醉犬进行了以下研究：1)获得了分级吸气负荷、高氧高碳酸血症和正碳酸低氧血症时的压力-流量关系；2)研究了腓肠肌电刺激后环腱后肌和鼻翼肌的肌电图反应；3)研究了颏舌肌电刺激对上气道阻力的影响。结果发现：(1)压力-流量关系随着吸气负荷、高血氧和缺氧的增加而升高；(2)完整神经对腓肠肌的电刺激开始时，环环肌腱样肌电图和鼻翼肌电图的反应迅速增加，而神经外周切端对腓肠肌的电刺激消失；(3)上呼吸道阻力随刺激频率依赖性而下降，特别是在20-50 Hz之间迅速下降。这些发现表明，呼吸肌和非呼吸肌的神经刺激和/或体液刺激会激活呼吸控制器，从而影响上气道通畅，而颏舌肌张力本身对于维持上气道通畅是重要的。

项目成果

Hiroshi miki, Wataru Hida, Chiyohiko Shindoh, Osamu Taguchi, Hiroshi Inoue and Tamotsu Takishima: "Dilation of upper airway by stimulation of genioglossus muscle in anesthetized dogs" Am Rev Respir Dis.

Hiroshi miki、Wataru Hida、Chiyohiko Shindoh、Osamu Taguchi、Hiroshi Inoue 和 Tamotsu Takishima：“通过刺激麻醉犬颏舌肌来扩张上呼吸道”Am Rev Respir Dis。

Hiroshi Miki他: Tohoku J exp.Med.153. 397-398 (1987)

Hiroshi Miki 等人：Tohoku J exp.Med.153 (1987)。

Hiroshi Miki他: Am Rev Respir Dcs.

Hiroshi Miki 等人：Am Rev Respir Dcs。

飛田渉他: 呼吸. 5. 1278-1286 (1986)

飞田渡 (Wataru Tobita) 等人：呼吸。5. 1278-1286 (1986)

滝島任他: 日本医事新報. 3292. 27-32 (1987)

Takishima，T. 等人：Nippon Iji Shinpo。3292. 27-32 (1987)