Delivery system responding to the abnormal G protein-coupled receptor signaling for diagnosis and treatment of cardiovascular diseases

响应异常 G 蛋白偶联受体信号传导的递送系统用于心血管疾病的诊断和治疗

• 批准号: 23310085
• 负责人: KANG JEONG-HUN
• 金额: $ 5.66万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23310085/
• 关键词: Ｇタンパク質共役受容体; プロテインキナーゼ; 細胞内シグナル; ナノ・バイオサイエンス; 循環器疾患; 薬物送達; ナノバイオサイエンス; Gタンパク質共役受容体

The purpose of this study was to develop the delivery system of therapeutic molecules responding to the abnormal G protein-coupled receptor signaling for diagnosis and treatment of cardiovascular disease. Novel peptide substrates with high affinity for abnormal cellular signals were identified. Delivery system consisted of hydrophilic neutral polymer as the main chain and peptide substrates as side chains. When the system/gene complex was transfected into cells, gene expression increased in abnormal cells overexpressing target signals, but very low expression was found in normal cell.

这项研究的目的是开发响应异常G蛋白偶联受体信号的治疗分子的递送系统，以诊断和治疗心血管疾病。鉴定出对异常细胞信号的高亲和力的新型肽底物。递送系统由亲水性中性聚合物作为主链和肽底物作为侧链组成。当将系统/基因复合物转染到细胞中时，基因表达在过表达靶信号的异常细胞中增加，但在正常细胞中发现非常低的表达。

项目成果

Nanotechnological strategies for tumor-targeted delivery of drugs or genes. In: Advances in Nanotechnology. Vol.8, Chapter 8

用于肿瘤靶向递送药物或基因的纳米技术策略。

• 发表时间: 2012
• 作者: R. Toita;Y. Katayama;J.H. Kang
• 通讯作者: J.H. Kang

Liver cell-targeted delivery of therapeutic molecules

• DOI: 10.3109/07388551.2014.930017
• 发表时间: 2016-01-02
• 期刊: CRITICAL REVIEWS IN BIOTECHNOLOGY
• 影响因子: 9
• 作者: Kang, Jeong-Hun;Toita, Riki;Murata, Masaharu
• 通讯作者: Murata, Masaharu

Diagnostic and therapeutic nanomaterials that respond to cellular environments. In: Nanotechnology; Diagnostics and Therapeutics. Vol.7, Chapter 17

对细胞环境做出反应的诊断和治疗纳米材料。

• 发表时间: 2013
• 作者: J.H. Kang;T. Riki;M. Murata
• 通讯作者: M. Murata

Effect of the introduction of condroitin sulfate into polymer-peptide conjugate responding to intracellular signals

将硫酸软骨素引入聚合物-肽缀合物对细胞内信号的响应效果

• 发表时间: 2011
• 期刊: Nanoscale Res. Lett
• 作者: T. Tomiyama;R. Toita;J-H. Kang;H. Koga;S. Shiosaki;T. Mori;T . Niidome;Y . Katayama
• 通讯作者: Y . Katayama

リポソーム組成物及び治療薬

脂质体组合物和治疗剂

• 发表时间: 2014