Delivery system responding to the abnormal G protein-coupled receptor signaling for diagnosis and treatment of cardiovascular diseases

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The purpose of this study was to develop the delivery system of therapeutic molecules responding to the abnormal G protein-coupled receptor signaling for diagnosis and treatment of cardiovascular disease. Novel peptide substrates with high affinity for abnormal cellular signals were identified. Delivery system consisted of hydrophilic neutral polymer as the main chain and peptide substrates as side chains. When the system/gene complex was transfected into cells, gene expression increased in abnormal cells overexpressing target signals, but very low expression was found in normal cell.