Fluid mechanical study on the platelet aggregation

本研究旨在通过实验和数值研究流体力学对血小板聚集的影响。在实验中，用激光共聚焦显微镜观察红细胞悬浮液中荧光染色的血小板，发现在红细胞存在的情况下，血小板在血管壁附近随机移动，其浓度增强。二元分散悬浮液的数值模拟结果表明，根据颗粒大小和物理性质的不同，悬浮颗粒倾向于在通道中心线附近或通道壁面附近流动。还发现，团聚体的生长速率取决于周围的流动和团聚体的旋转。因此，本研究提示与红细胞的流体力学相互作用在血流中血小板聚集的形成和生长中起着重要作用。

The present study was aimed to investigate the fluid mechanical effect on the platelet aggregation experimentally and numerically. In the experiment, the observation of fluorescence stained platelets in red cell suspension by a confocal Laser scanning microscope showed that platelets move randomly and their concentration is enhanced near the vessel wall in the presence of red cells. The numerical simulation for binary dispersed suspensions revealed that the suspended particles tend to flow near the channel centerline or near the channel wall, depending on the particle size and physical properties. It was also found that the growth rate of aggregation depends on the surrounding flow and the rotation of the aggregate. Thus, the present study suggests that the fluid mechanical interaction with red cells plays a significant role in the formation and growth of platelet aggregation in blood flow.