Studies on screening for substances which act on cancer stem cells established from tumors surgically excised from brain tumor patients.
Studies on screening for substances which act on cancer stem cells established from tumors surgically excised from brain tumor patients.
批准号:
23380067
负责人:
SHIN-YA Kazuo
金额:
$11.4万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
One of the biggest problems of cancer chemotherapy is the acquisition of drug resistance. Recent years, it has been considered that "cancer stem cell" plays a significant role in drug resistance. Most of tumor is originated from cancer stem cells, thus it is thought to be the severest malignant cells. Like this, cancer stem cells are promising targets for the development of antitumor drugs, however, cancer stem cells are difficult to be applied for drug screenings since it is unstable being to differentiate to various cell types. Glioblastoma multiforme (GBM) excised from cancer patients is stably shows the character of cancer stem cells when cultured in spheroid system. In this study, we performed the screening for substances which act on GBM cells using natural library.
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天然物のハイスル-プットランダムスクリーニングへの応用
在天然产物高通量随机筛选中的应用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[宮地朋子, 市川尚斉, 松井南, 藤岡昭三, 長田裕之, 浅見忠男, 中野雄司, 新家 一男]
通讯作者:
新家 一男
世界最大の天然物ライブラリーを用いたハイスループットランダムスクリーニング
利用世界上最大的天然产物库进行高通量随机筛选
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[中村郁子, 藤岡昭三, 栃尾尚哉, 伊藤晋作, 木川隆則, 嶋田幸久, 松岡信, 吉田茂男, 木下俊則, 浅見忠男, 瀬戸秀春, 中野雄司, 新家 一男]
通讯作者:
新家 一男
JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin
JBIR-129 和 -139,微生物来源的细胞毒性 34 元多元醇大环内酯
DOI:
10.1021/np3004358
发表时间:
2012
期刊:
J. Nat. Prod
影响因子:
--
作者:
[Teppei Kawahara, Ji-Hwan Hwang, Miho Izumikawa, Junko Hashimoto, Motoki Takagi and Kazuo Shin-ya]
通讯作者:
Motoki Takagi and Kazuo Shin-ya
天然物のハイスループットランダムスクリーニングへの応用
在天然产物高通量随机筛选中的应用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[H. Katayama, Y. Asahina, H. Hojo, 新家一男]
通讯作者:
新家一男
Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria
来自腐生真菌 Nectria 的细胞毒性倍半萜类化合物 MBJ-0009 和 MBJ-0010
DOI:
10.1038/ja.2013.45
发表时间:
2013
期刊:
J. Antibiot
影响因子:
--
作者:
[Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Noriaki Sakata, Toshio Tsuchida and Kazuo Shin-ya]
通讯作者:
Toshio Tsuchida and Kazuo Shin-ya
共 7 条
Studies on apoptosis regulators substances of microbial origin aiming at neuroprotection
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批准号:13660104
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2001
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负责人:SHIN-YA Kazuo
-
依托单位:
Studies on substances of microbial origin which protect central nervous system
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批准号:10660104
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1998
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负责人:SHIN-YA Kazuo
-
依托单位:
海外基金