Development of a novel type worm-like DDS penetrable into tumor tissue

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In this study, we attempted to develop a novel type worm-like DDS for overcoming drawbacks of conventional nanoDDS for anticancer therapy, such as, antigenicity of PEG, low cell affinity and low permeability into tumor tissue. As the results, we successfully developed charge-invertible liposomes, which can response to tumor microenvironment, and the capabilities of endosomal escape and cellular internalization and tumor accumulation comparable to PEG-liposomes were confirmed. Moreover, the worm-like nanostructures, which can penetrate into narrow space, were developed, and significantly high permeability into spheroids was achieved by improvement of physicochemical property of wick structure, modification with hyaluronidase and functional peptides. Then, integration of those functional liposomes, and evaluation of in vivo functionality was started.