Nitrergic function in life style-related diseases

扩张血管平滑肌和阴茎海绵体的氮能神经分别在脑循环和勃起的生理调节中起重要作用。本研究从生活方式相关疾病的实验模型大鼠(如高血压的SHR和糖尿病肥胖的ZDF大鼠)分离的海绵体上观察了氮能神经功能的变化。在实验模型大鼠中，由于收缩神经功能亢进或扩张神经功能减退或两者兼而有之，导致神经源性平滑肌扩张活性降低。海绵体nNOS表达减少可能是导致ZDF大鼠勃起功能障碍的原因之一。

Nitrergic nerves dilating smooth muscles of blood vessels and corpus cavernosum penis play an important role in the physiological regulation of cerebral circulation and erection, respectively. In the present study, change in nitrergic nerve function was examined in the corpus cavernosum isolated from experimental model rats of life style-related diseases such as SHR for hypertension and ZDF rats for diabetes with obese. In the experimental model rats, neurogenic dilating activity of smooth muscles was decreased due to hyperfunction of constricting nerves, hypofunction of dilating nerves, or both. Decreased expression of nNOS in the corpus cavernosum is suggested to cause erectile dysfunction in ZDF rats.