Development of cell-based therapy using dedifferentiated fat cells for treatment of intractable diseases in elderly patients

本研究旨在探讨去分化脂肪（DFAT）细胞移植治疗老年人常见疾病的有效性和安全性。自体移植DFAT细胞显著改善兔和猪后肢缺血模型的血流和血管密度。自体DFAT细胞移植也有助于兔骨缺损模型和卵巢切除诱导的骨质疏松模型中的骨再生。在接受DFAT细胞移植的任何动物中均未观察到肿瘤形成或异常细胞分化。这些结果表明，DFAT细胞移植是一种安全和有效的策略，治疗老年患者的难治性疾病。

We evaluated the therapeutic effect and safety of dedifferentiated fat (DFAT) cell transplantation in animal models of diseases, mainly occur in elderly people. Autologous implantation of DFAT cells significantly improved blood flow and vascular density in a rabbit and a porcine model of hindlimb ischemia. Autologous DFAT cell transplantation also contributed to bone regeneration in a rabbit bone defect model and an ovariectomy-induced osteoporosis model. Tumor formation or abnormal cell differentiation was not observed in any animal that received DFAT cell transplantation. These results suggest that DFAT cell transplantation is a safe and useful strategy for treatment of intractable diseases in elderly patients.