Analysis of hepatocarcinogenesis based on gender and mitochondrial biogenesis

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Oxidative stress plays an important role in hepatocarcinogenesis. Hepatitis C virus (HCV) is well known to induce the production of reactive oxygen species (ROS). In the present study we have shown that hepatitis C virus (HCV) core protein suppresses mitophagy (mitochondrial quality control) , which may lead to continuous induction of ROS production and inhibition of mitochondrial biogenesis. We also demonstrated that hepatic oxidative stress was augumented in ovariectomized transgenic mice expressing the HCV polyprotein by attenuation of antioxidant potential through inhibition of AMPK/PGC-1alpha signaling. These results may account in part for the mechanisms by which HCV-infected women are at high risk for HCC development when some period had passed after menopause.