Organ crosstalk and chronic inflammation in the pathogenesis of cardiovascular diseases
Organ crosstalk and chronic inflammation in the pathogenesis of cardiovascular diseases
批准号:
23390203
负责人:
MANABE Ichiro
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
In this project we analyzed how chronic inflammation that is initiated in obese adipose tissue affects the cardiovascular system in metabolic syndrome. We found that saturated fatty acids that are released from obese adipose tissue promote inflammation in the cardiovascular system ("fat-heart, fat-vessel crosstalk"). We also found that the heart and kidneys interact with each other in response to cardiac stress, and this interaction ("cardiorenal crosstalk") is important for the maintenance of cardiac homeostasis.
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Saturated Fatty Acid and TLR Signaling Link b Cell Dysfunction and Islet Inflammation
饱和脂肪酸和 TLR 信号传导通路 b 细胞功能障碍和胰岛炎症
DOI:
--
发表时间:
2012
期刊:
Cell Metabolism
影响因子:
29
作者:
[Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R]
通讯作者:
Nagai R
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Li Yuxin, 廣井透雄, 高山忠輝, 廣高史, 松本太郎, 齋藤穎, 平山篤志, Liao Ronglih, Liao James K, Manabe I]
通讯作者:
Manabe I
DOI:
10.1088/1468-6996/13/6/064218
发表时间:
2012-12-01
期刊:
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
影响因子:
5.5
作者:
[Fujiu, Katsuhito, Manabe, Ichiro, Nagai, Ryozo]
通讯作者:
Nagai, Ryozo
慢性炎症と心筋病理
慢性炎症与心肌病理学
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Ogawa T, Iwakura K, Hattori H, Iwai M, Suzuki O, Nakagawa T, Seno H, 眞鍋一郎]
通讯作者:
眞鍋一郎
Chronic inflammation in homeostasis and pathology in cardiometabolic syndrome and chronic kidney disease
心脏代谢综合征和慢性肾脏病的稳态和病理学中的慢性炎症
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[R. Kikura-Hanajiri, M. Kawamura, S. Kanno, T. Nagai, M. Takada, T. Mukai and Y. Goda, Manabe I]
通讯作者:
Manabe I
共 14 条
Alterations in cardiac macrophages in heart failure
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批准号:16K15437
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2016
-
负责人:MANABE Ichiro
-
依托单位:
Crosstalk in circadian clock and inflammatory program
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批准号:26670393
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2014
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负责人:MANABE Ichiro
-
依托单位:
Identification of noncoding RNAs that regulate macrophage dynamics in chronic inflammation
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批准号:25670381
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
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负责人:MANABE Ichiro
-
依托单位:
Macrophage trafficking in adipose tissue inflammation
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批准号:24659382
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2012
-
负责人:MANABE Ichiro
-
依托单位:
Elucidation of molecular mechanisms of lymphedema
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批准号:23659412
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
-
财政年份:2011
-
负责人:MANABE Ichiro
-
依托单位:
Transcription factor networks in blood vessel-metabolic system crosstalk and metabolic syndrome
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批准号:18390230
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.71万
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财政年份:2006
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负责人:MANABE Ichiro
-
依托单位:
Transcriptional regulation and signaling in the interaction between vascular cells and adipocytes in metabolic syndrome
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批准号:16590661
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2004
-
负责人:MANABE Ichiro
-
依托单位:
海外基金