Organ crosstalk and chronic inflammation in the pathogenesis of cardiovascular diseases

心血管疾病发病机制中的器官串扰和慢性炎症

• 批准号: 23390203
• 负责人: MANABE Ichiro
• 金额: $ 12.23万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390203/
• 关键词: メタボリックシンドローム; 心不全; 臓器連関; 慢性炎症; 脂肪酸

In this project we analyzed how chronic inflammation that is initiated in obese adipose tissue affects the cardiovascular system in metabolic syndrome. We found that saturated fatty acids that are released from obese adipose tissue promote inflammation in the cardiovascular system ("fat-heart, fat-vessel crosstalk"). We also found that the heart and kidneys interact with each other in response to cardiac stress, and this interaction ("cardiorenal crosstalk") is important for the maintenance of cardiac homeostasis.

在该项目中，我们分析了肥胖脂肪组织中引发的慢性炎症如何影响代谢综合征中的心血管系统。我们发现，从肥胖脂肪组织中释放的饱和脂肪酸会促进心血管系统的炎症（“脂肪-心脏，脂肪-血管串扰”）。我们还发现，心脏和肾脏相互作用，以响应心脏应激，这种相互作用（“心肾串扰”）是重要的心脏稳态的维持。

项目成果

Saturated Fatty Acid and TLR Signaling Link b Cell Dysfunction and Islet Inflammation

饱和脂肪酸和 TLR 信号传导通路 b 细胞功能障碍和胰岛炎症

• 发表时间: 2012
• 期刊: Cell Metabolism
• 影响因子: 29
• 作者: Eguchi K;Manabe I;Oishi-Tanaka Y;Ohsugi M;Kono N;Ogata F;Yagi N;Ohto U;Kimoto M;Miyake K;Tobe K;Arai H;Kadowaki T;Nagai R
• 通讯作者: Nagai R

Nickel-free stainless steel avoids neointima formation following coronary stent implantation

• DOI: 10.1088/1468-6996/13/6/064218
• 发表时间: 2012-12-01
• 期刊: SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
• 影响因子: 5.5
• 作者: Fujiu, Katsuhito;Manabe, Ichiro;Nagai, Ryozo
• 通讯作者: Nagai, Ryozo

Homeostatic inflammation in lipotoxicity and metabolic disease

脂毒性和代谢疾病中的稳态炎症

• 发表时间: 2012
• 作者: Li Yuxin;廣井透雄;高山忠輝;廣高史;松本太郎;齋藤穎;平山篤志;Liao Ronglih;Liao James K;Manabe I
• 通讯作者: Manabe I

慢性炎症と心筋病理

慢性炎症与心肌病理学

• 发表时间: 2012
• 作者: Ogawa T;Iwakura K;Hattori H;Iwai M;Suzuki O;Nakagawa T;Seno H;眞鍋一郎
• 通讯作者: 眞鍋一郎

Chronic inflammation in homeostasis and pathology in cardiometabolic syndrome and chronic kidney disease

心脏代谢综合征和慢性肾脏病的稳态和病理学中的慢性炎症

• 发表时间: 2012
• 作者: R. Kikura-Hanajiri;M. Kawamura;S. Kanno;T. Nagai;M. Takada;T. Mukai and Y. Goda;Manabe I
• 通讯作者: Manabe I