Clinical application and expression mechanisms for KL-6/MUC1 having a selectin ligand

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DIC (blood coagulation occurring in vessels) is an important prognostic factor in a severe lung injury called acute respiratory distress syndrome (ARDS). A retrospective study demonstrated that KL-6/MUC1 having a selectin ligand (SLAK) can predict the onset of DIC in ARDS. The SLAK had the better sensitivity and specificity for prediction of mortality than previously known factors and thus is a good prognostic biomarker in ARDS. During investigation on the mechanism for the synthesis of the molecules, we demonstrated that KL-6 could be expressed in mice expressing the human MUC1, although KL-6 is never expressed in mice. We also demonstrated that KL-6 could be a biomarker in mouse models of acute lung injury and bleomycin pulmonary fibrosis by using this transgenic mouse.