Clinical application and expression mechanisms for KL-6/MUC1 having a selectin ligand

具有选择素配体的KL-6/MUC1的临床应用和表达机制

• 批准号: 23390222
• 负责人: YOKOYAMA AKIHITO
• 金额: $ 11.4万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390222/
• 关键词: バイオマーカー; ムチン; KL-6; 肺障害; ﾑﾁﾝ; 急性呼吸促拍症候群; 肺線維症; 急性肺障害; MUC1; 非閉塞性肺疾患

DIC (blood coagulation occurring in vessels) is an important prognostic factor in a severe lung injury called acute respiratory distress syndrome (ARDS). A retrospective study demonstrated that KL-6/MUC1 having a selectin ligand (SLAK) can predict the onset of DIC in ARDS. The SLAK had the better sensitivity and specificity for prediction of mortality than previously known factors and thus is a good prognostic biomarker in ARDS. During investigation on the mechanism for the synthesis of the molecules, we demonstrated that KL-6 could be expressed in mice expressing the human MUC1, although KL-6 is never expressed in mice. We also demonstrated that KL-6 could be a biomarker in mouse models of acute lung injury and bleomycin pulmonary fibrosis by using this transgenic mouse.

DIC（血管内凝血）是严重肺损伤（称为急性呼吸窘迫综合征（ARDS））的重要预后因素。一项回顾性研究表明，具有选择素配体（SLAK）的KL-6/MUC 1可预测ARDS中DIC的发生。SLAK对预测ARDS患者死亡率的敏感性和特异性均优于已知的因素，是一种良好的预后生物标志物。在分子合成机制的研究中，我们证明了KL-6可以在表达人MUC 1的小鼠中表达，尽管KL-6在小鼠中从未表达。我们还证明，KL-6可以在急性肺损伤和博莱霉素肺纤维化的小鼠模型，通过使用这种转基因小鼠的生物标志物。

项目成果

ヒトMUC1トランスジェニックマウスを用いた肺障害モデルの解析

人MUC1转基因小鼠肺损伤模型分析

• 发表时间: 2012
• 作者: 酒井瑞;窪田哲也;大西広志;横山彰仁
• 通讯作者: 横山彰仁

Pulmonary complications in patients with hematologic diseases

血液病患者的肺部并发症

• 发表时间: 2012
• 作者: Hiroshi Ohnishi;Kazuto Togitani;Mizu Sakai;Ayuko Taniguchi;Takayuki Ikezoe;Tetsuya Kubota;Akihito Yokoyama
• 通讯作者: Akihito Yokoyama

Analysis of lung injury models by using human MUC1 transgenic mice.

使用人MUC1转基因小鼠分析肺损伤模型。

• 发表时间: 2016
• 作者: Tetsuya Kubota;Mizu Sakai;Shin Akita;Shigeo Kawase;Hiroshi Ohnishi;Akihito Yokoyama
• 通讯作者: Akihito Yokoyama

Recombinant human soluble thrombomodulin safely and effectively rescues acute promyelocytic leukemia patients from disseminated intravascular coagulation

• DOI: 10.1016/j.leukres.2012.08.012
• 发表时间: 2012-11-01
• 期刊: LEUKEMIA RESEARCH
• 影响因子: 2.7
• 作者: Ikezoe, Takayuki;Takeuchi, Asako;Yokoyama, Akihito
• 通讯作者: Yokoyama, Akihito

CO2ナルコーシス.今日の治療と看護

CO2麻醉今日治疗及护理

• 发表时间: 2013
• 作者: Takashi Yamane;Akihito Yokoyama;Yo shihiro Kitahara;Yoshinori Haruta;Kiminori Yamane;Noboru Hattori;Hit oshi Hara;Nobuoki Kohno .;横山彰仁;横山彰仁
• 通讯作者: 横山彰仁