Mechanisms for systemic inflammation in COPD

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We collected visceral fat tissues (n=120) during abdominal surgery for mainly early abdominal malignancies and investigated inflammatory cells including macrophages and cytokines. The COPD group having obstructive ventilatory impairment and smoking history did not have significantly increased number of macrophages which is a marker for fat tissue inflammation, when compared to non-smokers or healthy smokers. Further, in the COPD group with high serum CRP tended to have higher visceral fat macrophages than those with low CRP, but did not reach to be significant. In the entire study, both BMI and %VC were significantly correlated with the number of visceral fat macrophages independently by multivariate analysis. These results suggest that visceral fat inflammation is not involved in systemic inflammation of COPD, but is associated with lower lung volume.