Mechanisms for systemic inflammation in COPD

COPD 全身炎症的机制

• 批准号: 24659405
• 负责人: YOKOYAMA AKIHITO
• 金额: $ 2.41万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659405/
• 关键词: COPD; 併存症; 内臓脂肪; 全身性炎症; 閉塞性肺疾患; TNF

We collected visceral fat tissues (n=120) during abdominal surgery for mainly early abdominal malignancies and investigated inflammatory cells including macrophages and cytokines. The COPD group having obstructive ventilatory impairment and smoking history did not have significantly increased number of macrophages which is a marker for fat tissue inflammation, when compared to non-smokers or healthy smokers. Further, in the COPD group with high serum CRP tended to have higher visceral fat macrophages than those with low CRP, but did not reach to be significant. In the entire study, both BMI and %VC were significantly correlated with the number of visceral fat macrophages independently by multivariate analysis. These results suggest that visceral fat inflammation is not involved in systemic inflammation of COPD, but is associated with lower lung volume.

我们在腹部手术期间收集内脏脂肪组织（n=120），主要用于早期腹部恶性肿瘤，并研究炎症细胞，包括巨噬细胞和细胞因子。与非吸烟者或健康吸烟者相比，具有阻塞性呼吸障碍和吸烟史的COPD组的巨噬细胞数量没有显著增加，巨噬细胞是脂肪组织炎症的标志物。此外，高血清CRP的COPD组的内脏脂肪巨噬细胞倾向于高于低CRP组，但未达到显著性。在整个研究中，通过多变量分析，BMI和%VC均与内脏脂肪巨噬细胞的数量独立地显著相关。这些结果表明，内脏脂肪炎症不参与COPD的全身性炎症，但与肺容量降低有关。

项目成果

A novel treatment strategy targeting shugoshin 1 in hematological malignancies.

• DOI: 10.1016/j.leukres.2012.10.002
• 发表时间: 2013
• 期刊: Leukemia research
• 影响因子: 2.7
• 作者: Jing Yang;T. Ikezoe;C. Nishioka;A. Yokoyama

Assessment of como rbidites in COPD

COPD 合并症的评估

• 发表时间: 2013
• 作者: S Kawase ;M Takaoka;S Miyamoto ,H Ohnishi ;T Kubota,T Namikawa,K Hana zaki ;A Yokoyama.;Akihito Yokoyama.
• 通讯作者: Akihito Yokoyama.

Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study

• DOI: 10.1093/aje/kwq426
• 发表时间: 2011-03-15
• 期刊: AMERICAN JOURNAL OF EPIDEMIOLOGY
• 影响因子: 5
• 作者: Doi, Mihoko;Hattori, Noboru;Kohno, Nobuoki
• 通讯作者: Kohno, Nobuoki

Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids

• DOI: 10.1016/j.jaci.2013.04.050
• 发表时间: 2013-08-01
• 期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
• 影响因子: 14.2
• 作者: Kanemitsu, Yoshihiro;Matsumoto, Hisako;Mishima, Michiaki
• 通讯作者: Mishima, Michiaki

Low Lung Volume Is Associated W ith Adipose Tissue Inflammation

肺容量低与脂肪组织炎症有关

• 发表时间: 2013
• 作者: Kawase S;Miyamoto S;Ohnishi H;Kub ota T;Namikawa T;Hanazaki;Yokoyam a A.
• 通讯作者: Yokoyam a A.