Molecular analysis of cell stress regulation by molecular chaperon and application for diabetes treatment

诱导分子伴侣如BiP或HSP72作用于胰岛素敏感组织，改善体内和体外葡萄糖稳态、胰岛素信号传导和内质网抗逆性。另一方面，BiP或HSP72的衰减导致葡萄糖处理功能受损和内质网抗逆性降低。在HSP72过表达的基因表达分析中，AMPK、PGC-1a和Sirt1 mRNA不受调控。这些分子可能对HSP72的诱导有抗糖尿病作用。

Induction of molecular chaperone, such as BiP or HSP72 on insulin sensitive tissues improved glucose homeostasis, insulin signaling and ER stress resistance both in vitro and in vivo. On the other hand, attenuation of BiP or HSP72 resulted in impairment of glucose handling and less ER stress resistance.On analyses of gene expressions when HSP72 was over expressed, AMPK, PGC-1a and Sirt1 mRNA were un-regulated. These molecules may exert anti-diabetic effects upon HSP72 induction.