Development of novel treatment for type 2 diabetes by regulating cellular stresses targeted to molecular chaperone.

诱导Hsp72或BiP等分子伴侣有助于改善糖尿病患者的葡萄糖稳态。特别是，这些诱导可以治疗几种类型的糖尿病，因为这些诱导分别对环境、遗传或内质网应激引起的糖尿病有效。因此，我们得出结论，诱导分子伴侣，如Hsp72或BiP，降低细胞应激和慢性炎症，从而改善胰岛素抵抗。

Induction of molecular chaperones, such as Hsp72 or BiP contributes to improve glucose homeostasis in diabetes. Especially, these inductions can be expected to treat several types of diabetes, because these inductions were effective to diabetes originated from environmental, genetic or ER stress, respectively. We therefore conclude that induction of molecular chaperone, such as Hsp72 or BiP, decreases cellular stresses and chronic inflammation, resulting in improvement of insulin resistance.