Development of new diagnosis approaches for detecting cardiovascular dysfunction in patients with respiratory disease using positron emission tomography

PH患者右室(RV)氧化代谢增加与平均PAP、PVR和BNP等预后指标相关。WHO功能II~III级PH的患者RV功率和效率也有所增加。这些发现可能提示心肌对PAP升高的能量适应性反应。高强度PH处理降低了RV氧化代谢，提高了RV容量/耗氧指数。在这个项目中，我们开发了可能的新的预后标志物和有用的治疗监测标志物。F-18氟脱氧葡萄糖(FDG)被认为是心脏受累结节病(CS)的诊断标志物。我们报告了左心室的心电图异常和阳性的F-18FDG摄取之间的关系。这表明活动性炎症与节律异常有关。我们还报道了CS患者的心脏交感神经功能降低。这些发现可能有助于理解疾病的发病机制。

Right ventricular (RV) oxidative metabolism increased in patients with PH in association with prognostic markers such as mean PAP, PVR, and BNP.. Patients with WHO functional class II to III PH also had increased RV power and efficiency. These findings may indicate a myocardial energetics adaptation response to increasing PAP. Intensive PH treatments reduced RV oxidative metabolism and improved RV volume/oxygen consumption index. In this project, we developed possible new prognostic markers and useful treatment monitor markers in patients with PH.F-18 flucorodeoxyglucose (FDG) has been considered to be a diagnostic marker of cardiac involvement sarcoidosis (CS). We reported the association between the ECG abnormalities and positive F-18 FDG uptake in LV. This indicates active inflammation is associated with rhythm abnormalities. We also reported the reduced cardiac sympathetic nervous function in CS. These findings may contribute the understanding the disease mechanisms.