Development of new anti-tumor therapy for malignant glioma using a drug incorporating polymeric micelle attached with a specific antibody for glioma cancer stem cell

我们开发了通过将恶性胶质瘤细胞皮下植入裸小鼠来浓缩和富集胶质瘤干细胞（GSC）的方法。通过这种方法可以获得含有丰富GSCs的肿瘤细胞。我们已经通过一些分子生物学技术鉴定了一种新的GSC特异性分子，然而，我们还没有找到最合适的分子。同时，我们将替莫唑胺与纤维蛋白胶混合，在小鼠模型中研究了这种药物的抗肿瘤作用，发现了这种药物的疗效，我们认为应该寻找一种最佳的分子靶向药物。

We developed the method for concentrating and enriching Glioma stem cell(GSC) by subcutaneous implantation of malignant glioma cells into nude mice. By this method we could obtained tumor cells including abundant GSCs. We have been identifying a new molecule specific for GSC by some molecular biological techniques, however, we have not yet found the most suitable molecule. In parallel, we mixed temozolomide and fibrin glue and investigated the anti-tumor effect of this drug in the mouse model.We found the efficacy of this drug and we think we should search for an optimal molecular target drug.