Deep brain stimulation and neuronal reorganization

脑深部电刺激（DBS）的临床作用机制尚不清楚;然而，DBS可能通过脑神经元重组发挥作用。通过动物模型，我们发现描述因子Pax 6在丘脑底核（subthalamic nucleus，DBS）周围结构中表达，可能成为DBS后神经元再生的一个有用的标志物。在患有帕金森病的人类受试者中，STN-DBS的效果与白色物质体积显著相关，这表明基底节-丘脑皮质回路的组件之间的保留的连接性可能是电刺激有效性所必需的。我们继续研究建立一个稳定的动物模型STN-DBS，以检测是否DBS实质上诱导哺乳动物大脑中的神经元再生。

Mechanisms underlying clinical effect of deep brain stimulation (DBS) are still unclear ; however, DBS may act through neuronal reorganization of the brain. By using animal model, we found that description factor Pax6 is expressed in the surrounding structure of subthalamic nucleus (STN) and may become a useful marker for neuronal regeneration subsequent to DBS. In human subjects with Parkinson's disease, effect of STN-DBS was significantly correlated to white matter volume, suggesting preserved connectivity between components of the basal ganglia-thalamocortical circuit may be required for the effectiveness of electrical stimulation. We continue to study to establish a stable animal model for STN-DBS to detect whether DBS substantially induces neuronal regeneration in the mammalian brain.