Deep brain stimulation and neuronal reorganization

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Mechanisms underlying clinical effect of deep brain stimulation (DBS) are still unclear ; however, DBS may act through neuronal reorganization of the brain. By using animal model, we found that description factor Pax6 is expressed in the surrounding structure of subthalamic nucleus (STN) and may become a useful marker for neuronal regeneration subsequent to DBS. In human subjects with Parkinson's disease, effect of STN-DBS was significantly correlated to white matter volume, suggesting preserved connectivity between components of the basal ganglia-thalamocortical circuit may be required for the effectiveness of electrical stimulation. We continue to study to establish a stable animal model for STN-DBS to detect whether DBS substantially induces neuronal regeneration in the mammalian brain.