Study for insulin resistance in obstetric and gynecologic diseases

胰岛素抵抗（IR）在某些情况下增加，如怀孕，多囊卵巢综合征（PCOS）和子宫内膜癌。在这项研究中，我们旨在揭示IR在这种情况下的作用。IR与妊娠期糖尿病（GDM）密切相关，尤其是与肥胖妇女密切相关。IR还与脂肪细胞因子的代谢密切相关。因此，在子宫内暴露于高脂肪饮食可能通过脂肪细胞因子、脂联素和瘦素基因表达的表观遗传修饰导致代谢综合征样现象。PCOS患者IR增加，GDM和先兆子痫的发生率增加。I型子宫内膜癌与肥胖相关的生物学参数比II型子宫内膜癌有统计学意义的增加。脂肪组织中皮下脂肪堆积是发生I型子宫内膜癌的重要危险因素，与IR密切相关。

Insulin resistance (IR) increases under some conditions such as pregnancy, polycystic ovary syndrome (PCOS) and endometrial cancer. In this study we aimed to reveal the roll of IR in such conditions. IR is closely related with gestational diabetes mellitus (GDM), especially in women with obesity. IR was also closely related with the metabolism of adipocytokine. Thus, exposure to a high-fat diet in utero might cause a metabolic syndrome-like phenomenon through epigenetic modifications of adipocytokine, adiponectin, and leptin gene expression. IR is increased in PCOS patients and the occurrence of GDM and preeclampsia increased in these patients. Type I endometrial cancer has a statistically significant increase in obesity-related biological parameters than type II endometrial cancer. Subcutaneous fat accumulation in adipose tissue is a strong risk factor for developing type I endometrial cancer and also close relationship with IR.