Clarification about the antidepressant effect of salivary gland BDNF due to chewing

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In this study, we examined whether there are association between antidepressant and BDNF increased by chewing. The BDNF strong expression mouse derived from salivary gland showed a high BDNF blood symptom by ELISA system. Using this Tg mouse, we examined an action physiologic change by open field test and an elevated cross maze. The center invasion number of times, sojourn time in open field test was significantly high in the open arm invasion number of times with Tg mouse in the elevated cross maze. It was suggested that salivary gland BDNF showed an antianxiety effect in the central nervous system. In summary, by the animal experiment, the salivary gland BDNF may be antidepressant effect, but it will be necessary to examine it in detail in future whether BDNF increased by human chewing has antidepressant effects.