The study on stressful lesion suppression mechanism of the BDNF derived from a salivary gland

我们培育了唾液腺BDNF高表达的Tg小鼠。我们制备了腮腺特异性启动子PSP、小鼠BDNF和HA标签组成的构建体。由于用唾液腺产生的BDNF是由加入HA标签的蛋白构成的，就该Tg小鼠的特点而言，它是具有内在BDNF和区分可能性的具有划时代意义的Tg小鼠，并且可以证明唾液腺产生BDNF的体内行为。Tg小鼠对应激负荷具有防御倾向。

We developed the Tg mouse with high BDNF expression in the salivary gland. We manufactured the construct composed of PSP parotid gland-specific for the promoter, mouse BDNF and HA tag. Because the BDNF produced with a salivary gland is composed as the protein which an HA tag was added to as for the characteristic of this Tg mouse, it is the epoch-making Tg mouse which it is possible for intrinsic BDNF and distinction, and can prove in vivo behavior of the salivary gland production BDNF. This Tg mouse had a defense tendency for stress load.