A Challenge to the expansion of indications in periodontal tissue regeneration using FGF-2 by analyzing cross talk between signal molecules

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To elucidate the possibility to the expansion of indications in the periodontal tissue regeneration using fibroblast growth factor-2 (FGF-2), we examined the longitudinal prognosis of FGF-2 application in the clinical trials. Furthermore, we evaluated the efficacy combining FGF-2 and adipose tissue- derived stem cells (ADSC) for periodontal tissue regeneration in the severe periodontal tissue defects of beagle dogs, and investigated the signal transduction following the FGF-2 stimulations in mouse periodontal ligament cells.In result, the long-term safeties of FGF-2 application in human and the expansion of efficacy combining FGF-2 and ADSC for periodontal tissue regeneration in the severe periodontal tissue defects of beagle dogs were showed. In addition, it was clear that there were the intracellular signaling mechanisms governed by the cross talk between FGF-2 and vascular endothelial growth factor or bone morphogenetic protein 2 in the periodontal tissue regeneration.