Passive smoking-induced epigenetic regulation in tooth・periodontal tissue-associated genes.

被动吸烟诱导的牙齿·牙周组织相关基因的表观遗传调控。

• 批准号: 23659975
• 负责人: KITAMURA Masahiro
• 金额: $ 2.25万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659975/
• 关键词: 喫煙; 歯周病; 受動喫煙; エピジェネティクス; 歯科疾患感受性

In this study, we established the mouse model of experimental periodontitis similar to human periodontal lesion and investigated the effects of cigarette smoke constituents for pathogenesis of periodontal diseases using this model. In result, we found that intraperitoneally administration of nicotine or cigarette smoke condensate accelerated alveolar bone loss in mice compared with control group. These results indicate the useful animal model to examine the effects of smoking for oral diseases in human.

本研究建立了与人类牙周病变相似的实验性牙周炎小鼠模型，并利用该模型研究了香烟烟雾成分在牙周病发病机制中的作用。结果，我们发现与对照组相比，腹腔注射尼古丁或香烟烟雾凝聚物加速了小鼠的牙槽骨丢失。这些结果为研究吸烟对人类口腔疾病的影响提供了有益的动物模型。

项目成果

Periodontal Regeneration and FGF-2

牙周再生和 FGF-2

• 发表时间: 2013
• 期刊: Inflammation and Regeneration
• 影响因子: 8.1
• 作者: Kojima Y;Yanagita M;Yamada S;Kitamura M and Murakami S
• 通讯作者: Kitamura M and Murakami S

Mini-review : Periodontal regeneration and FGF-2

小回顾：牙周再生和 FGF-2

• 发表时间: 2013
• 期刊: Inflammation and Regeneration
• 影响因子: 8.1
• 作者: Kojima Y;Yanagita M;Yamada S;Kitamura M;Murakami S
• 通讯作者: Murakami S

Immunomodulation of dendritic cells differentiated in the presence of nicotine with lipopolysaccharide from Porphyromonas gingivalis.

• DOI: 10.1111/j.1600-0722.2012.00992.x
• 发表时间: 2012-10
• 期刊: European journal of oral sciences
• 影响因子: 1.9
• 作者: M. Yanagita;K. Mori;R. Kobayashi;Y. Kojima;M. Kubota;K. Miki;S. Yamada;M. Kitamura;S. Murakami

Supportive periodontal therapyの長期的効果の検討

检查支持性牙周治疗的长期效果

• 发表时间: 2011
• 作者: 山羽聡子;北村正博;島美和子;久保田実木子;坂口香穂里;西村誠ら
• 通讯作者: 西村誠ら

Adiponectin regulates functions of gingival fibroblasts and periodontal ligament cells

• DOI: 10.1111/j.1600-0765.2012.01467.x
• 发表时间: 2012-10-01
• 期刊: JOURNAL OF PERIODONTAL RESEARCH
• 影响因子: 3.5
• 作者: Iwayama, T.;Yanagita, M.;Murakami, S.
• 通讯作者: Murakami, S.