Practical applications of saliva test to grasp the condition of HIV-1 infected patients

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The aim of our study is to evaluate the efficacy of a regimen or monitor the compliance of patients treated with antiretroviral therapy. Another aim is to develop a method for determination of HIV-1 infection period of novel patients.First, we established a method to measure drug concentrations in plasma and saliva. Then, we measured drug concentrations in plasma and saliva and found significant correlations were evident between drug concentrations in saliva and those in plasma, so the possibility of using saliva was suggested. Second, we generated a hypothesis that HIV-1 infected patient's saliva have no infectivity because HIV-1 RNA in saliva were damaged. Then, we established a method for validate this hypothesis.These studies are valuable for HIV-1 infected patients with more convenient clinical examination or determination for the period of HIV-1 infection.