Research in Kenya for the development of diagnosis of latent and active tuberculosis

结核病是世界范围内发现的致命传染病，仍然是一个主要的公共卫生问题。大多数结核病例是由潜伏结核分枝杆菌感染引起的。然而，LTBI和结核感染的风险在很大程度上是未知的。我们对非洲肯尼亚结核病流行地区进行了全面的健康调查。在这项研究中，来自肯尼亚Mbita和Kwale两个不同地点的学校的627名儿童入学。并进行了血液生化分析、寄生虫和细菌性病原体感染检测等综合调查。我们发现潜伏抗原结核分枝杆菌是诊断LTBI更敏感的候选抗原，钩虫感染是除活动性结核外结核分枝杆菌感染的风险。

Tuberculosis is deadly infectious diseases found worldwide and remains a leading public health problem. The majority of TB cases arise from latent Mycobacterium tuberculosis infection (LTBI). However the risk of LTBI and development of TB from infection is largely unknown. We conducted comprehensive health survey in TB endemic area, Kenya Africa. In this study, 627 children from schools situated in two different sites, Mbita and Kwale districts, Kenya were enrolled. And we conducted comprehensive survey including biochemical analysis of blood and detection of infections of parasitic and bacterial pathogens. We found latent antigens M. tuberculosis is a candidates for more sensitive diagnosis of LTBI and hookworm infection is a risk of Mycobacterium tuberculosis infection besides active tuberculosis.