The role of olig2-derived astrocytes in subthalamic nucleus of adult mouse

在这项研究中，我们发现Olig2阳性细胞构成了成年小鼠前脑星形胶质细胞的一个亚群，并特异性分布在基底节区，包括丘脑底核（STN）和苍白球。众所周知，这两个核是帕金森病深部脑刺激（DBS）的靶区。为了了解该区域olig2星形胶质细胞的特性，我们使用Olig2CreER: ROSA-GAP43-EGFP双转基因小鼠制作半帕金森病模型。注射阿吗啡后，小鼠表现出旋转行为，反映了多巴胺能活动的不平衡。在这个实验范例中，我们发现olig2星形胶质细胞在基底节区激活侧具有比对侧更复杂的丛状形态，特别是在STN中。这些发现提示星形胶质细胞的形态与基底神经节核的神经元活动密切相关。

In this study, we found that Olig2 positive cells constitute a subpopulation of astrocytes in the adult mouse forebrain and distribute specifically in the basal ganglia including subthalamic nucleus (STN) and the globus pallidus. It is well known that these two nuclei are target areas for deep brain stimulation (DBS) in Parkinson's disease. To know the property of Olig2-astrocyte in the area, we made a hemi-Parkinson's disease model using Olig2CreER: ROSA-GAP43-EGFP double transgenic mouse. Upon apomorphine injection, the mice exhibited rotation behaviors that reflected imbalance of dopaminergic activities. In this experimental paradigm, we found that Olig2-astrocyte had more complex bushy morphologies in the activated side of the basal ganglia, especially in the STN than in the contralateral side. These findings suggest that morphologies of astrocytes are closely related to neuronal activities in the basal ganglionic nuclei.