Understanding of brain stimulation inducing brain plasticity by means of simultaneous neuroimaging

非侵入性磁电脑刺激使我们能够在一段时间内调节神经功能。因此，将脑刺激技术用于神经精神疾病的治疗似乎是可能的。然而，大脑刺激如何改变神经活动，从而改变行为仍不清楚。在这里，我们通过结合脑刺激和功能性磁共振成像来解决这个问题。我们发现，脑刺激在一定时间内改变了与受刺激部位相连的神经网络的功能。我们还发现，大脑刺激的效果存在很大的主体间差异，这在一定程度上是由于个体使用大脑的方式存在主体间差异。我们将进一步推进这些研究，以建立脑刺激作为神经精神疾病的治疗选择。

Non-invasive magnetic and electric brain stimulation allows us to modulate neural functions for a certain period of time. It thus seems possible to use brain stimulation technique for therapeutic purpose in neuro-psychiatric disorders. However, it remains unclear how brain stimulation changes neural activity, thereby modifying behaviors. Here we addressed this question by combining brain stimulation with functional magnetic resonance imaging. We found that brain stimulation modifies functions of neural network connected with the stimulated site for a certain period of time. We also found that large inter-subject variability for the effects of brain stimulation, and this was in part accounted for by inter-subject variability of how an individual uses his/her brain. We will further advance these lines of research toward establishment of brain stimulation as a therapeutic option for neuro-psychiatric disorders.