Toward therapeutic systems for Alzheimer's Disease by removal of blood Abeta: Investigation of Abeta in the brain of dialysis patients

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To create therapeutic systems for Alzheimer's Disease by removal of blood Abeta, the followings were investigated regarding hemodialysis which effectively removes blood Abeta; 1) Abeta depositions as senile plaques in the postmortem brains of hemodialysis patients were significantly less than those of patients without dialysis. 2) The concentrations of plasma Abeta increased along with the decline of renal functions. Moreover, the renal failure patients without hemodialysis and with poorer renal functions showed lower cognitive functions. 3) Along with the initiation of hemodialysis of 5 renal failure patients (64.0+-12.6 y.o.), the concentration of blood Abeta1-40, Abeta1-42, Abeta-oligomers were decreased and the cognitive functions were improved to or kept in full scores.These results indicates that the blood Abeta reduction systems is worth investigating further as therapeutic systems for Alzheimer's Disease.