Creation and evaluation of the novel concept of the therapeutic blood purification system for Alzheimer's Disease by the removal of blood amyloid beta

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We intend to develop the new therapeutic system for Alzheimer's Disease (AD) by removal of blood amyloid beta (Aβ) which may reduce brain Aβ, one of the major cause of AD. As the first step, we investigated suitable materials for Aβ removal, and the change of plasma Aβ by blood purification with the Aβ removal materials.1.Two effective adsorbents for Aβ removal were found. Around 50% of plasma Aβs were reduced by extracorporeal system with one of the two adsorbetns.2.Dialyzers also effectively removed plasma Aβs, which triggered the large influx of Aβs into the blood. The cognitive functions of the patients remained, although the plasma Aβ concentrations were high. The patients of longer dialysis vintage showed higher cognitive functions. Conceivably then, it is suggested that the removal of blood Aβ may maintain or improve the cognitive functions.