R&D of a portable ultrafiltration system with a small centrifugal pump

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A portable hemofiltration system has been developed for emergency use as well as home care or disaster care in future. Ultrafiltration is adopted not to use 120 L dialysis water and a centrifugal pump was adopted for simple usability. Regarding the newly developed centrifugal pumps, the first model showed 30% hemolysis and the second model showed 5% hemolysis compared with that of a conventional extracorporeal pump. High hemolysis was found to be caused by the wear of a female pivot. In vitro anti-thrombogenicity tests revealed almost no thrombus except around a pivot bearing. Regarding a hemofiltration experiment, though blood circulation flow and ultrafiltration flow was able to be kept constant this time, a similar performance should be kept even for a case of fouling or hollow fiber clogging.