Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury

运动抑制大鼠脑外伤后神经元凋亡并改善脑功能

• 批准号: 23500629
• 负责人: ITOH Tatsuki
• 金额: $ 3.41万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500629/
• 关键词: リハビリテーション; 神経再生; 運動; 脳外傷; 高次脳機能改善; 酸化ストレス; アポトーシス; 神経保護作用; 神経再生促進効果; 神経細胞死; 高次機能改善

we investigate the effect of exercise on morphology and cerebral function following TBI in rats. Wistar rats received TBI by a pneumatic controlled injury device and were randomly divided into two groups: 1) non-exercise group and 2) exercise group. The exercise group ran on a treadmill. Immunohistochemical and behavioral studies were performed following TBI. The number of ssDNA-positive cells early after TBI was significantly reduced in the exercise group. Furthermore, most ssDNA-positive cells in the non-exercise group co-localized with neuronal cells. However, in the exercise group, few ssDNA-positive cells co-localized. In addition, there was a significant increase in neuronal cell number and improvement in cerebral dysfunction after TBI in the exercise group. These results indicate that exercise following TBI inhibits neuronal apoptotic cell death, which results in an improvement of cerebral dysfunction.

本研究旨在探讨运动对创伤性脑损伤大鼠脑组织形态学和脑功能的影响。Wistar大鼠采用气动致伤装置致伤，随机分为两组：1）非运动组和2）运动组。运动组在跑步机上跑步。TBI后进行免疫组织化学和行为学研究。在运动组中，TBI后早期ssDNA阳性细胞的数量显著减少。此外，大多数ssDNA阳性细胞在非运动组与神经元细胞共定位。然而，在运动组中，很少有ssDNA阳性细胞共定位。此外，运动组脑外伤后神经元细胞数量显著增加，脑功能障碍得到改善。这些结果表明，TBI后的运动抑制神经元凋亡细胞死亡，这导致脑功能障碍的改善。

项目成果

Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2

• DOI: 10.1016/j.mce.2012.05.002
• 发表时间: 2012-09-25
• 期刊: MOLECULAR AND CELLULAR ENDOCRINOLOGY
• 影响因子: 4.1
• 作者: Tsubaki, Masanobu;Satou, Takao;Nishida, Shozo
• 通讯作者: Nishida, Shozo

Increased apoptotic neuronal cell death And cerebral dysfunction after traumatic brain injury in aged rats

老年大鼠脑外伤后神经细胞凋亡增加和脑功能障碍

• 发表时间: 2013
• 期刊: Brain Struct Funct
• 影响因子: 3.1
• 作者: Itoh T;Imano M;Nishida S;Tsubaki M;Mizuguchi N;Hashimoto S;Ito A;Satou T
• 通讯作者: Satou T

Delay of Stroke Onset by Milk Proteins in Stroke-Prone Spontaneously Hypertensive Rats

• DOI: 10.1161/strokeaha.111.618496
• 发表时间: 2012-02-01
• 期刊: STROKE
• 影响因子: 8.3
• 作者: Chiba, Tsuyoshi;Itoh, Tatsuki;Ezaki, Osamu
• 通讯作者: Ezaki, Osamu

Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury

• DOI: 10.1007/s00702-012-0918-4
• 发表时间: 2013-05-01
• 期刊: JOURNAL OF NEURAL TRANSMISSION
• 影响因子: 3.3
• 作者: Itoh, Tatsuki;Tabuchi, Masaki;Satou, Takao
• 通讯作者: Satou, Takao

緑茶飲料による脳外傷後の神経保護作用及び脳機能の改善効果の検討

绿茶饮料对脑外伤后神经保护作用及脑功能改善作用的考察

• 发表时间: 2013
• 作者: 伊藤龍生;橋本重夫;伊藤彰彦;佐藤隆夫
• 通讯作者: 佐藤隆夫