Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury

本研究旨在探讨运动对创伤性脑损伤大鼠脑组织形态学和脑功能的影响。Wistar大鼠采用气动致伤装置致伤，随机分为两组：1）非运动组和2）运动组。运动组在跑步机上跑步。TBI后进行免疫组织化学和行为学研究。在运动组中，TBI后早期ssDNA阳性细胞的数量显著减少。此外，大多数ssDNA阳性细胞在非运动组与神经元细胞共定位。然而，在运动组中，很少有ssDNA阳性细胞共定位。此外，运动组脑外伤后神经元细胞数量显著增加，脑功能障碍得到改善。这些结果表明，TBI后的运动抑制神经元凋亡细胞死亡，这导致脑功能障碍的改善。

we investigate the effect of exercise on morphology and cerebral function following TBI in rats. Wistar rats received TBI by a pneumatic controlled injury device and were randomly divided into two groups: 1) non-exercise group and 2) exercise group. The exercise group ran on a treadmill. Immunohistochemical and behavioral studies were performed following TBI. The number of ssDNA-positive cells early after TBI was significantly reduced in the exercise group. Furthermore, most ssDNA-positive cells in the non-exercise group co-localized with neuronal cells. However, in the exercise group, few ssDNA-positive cells co-localized. In addition, there was a significant increase in neuronal cell number and improvement in cerebral dysfunction after TBI in the exercise group. These results indicate that exercise following TBI inhibits neuronal apoptotic cell death, which results in an improvement of cerebral dysfunction.