Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury

点击翻译按钮获取中文摘要

we investigate the effect of exercise on morphology and cerebral function following TBI in rats. Wistar rats received TBI by a pneumatic controlled injury device and were randomly divided into two groups: 1) non-exercise group and 2) exercise group. The exercise group ran on a treadmill. Immunohistochemical and behavioral studies were performed following TBI. The number of ssDNA-positive cells early after TBI was significantly reduced in the exercise group. Furthermore, most ssDNA-positive cells in the non-exercise group co-localized with neuronal cells. However, in the exercise group, few ssDNA-positive cells co-localized. In addition, there was a significant increase in neuronal cell number and improvement in cerebral dysfunction after TBI in the exercise group. These results indicate that exercise following TBI inhibits neuronal apoptotic cell death, which results in an improvement of cerebral dysfunction.