Effects of voluntary wheel running and aging on mechanical vasodilation of the feed arteries of rat soles muscle.

随意跑轮和衰老对大鼠足底肌肉供血动脉机械性血管舒张的影响。

• 批准号: 23500771
• 负责人: MAEDA Junichi
• 金额: $ 3.41万
• 依托单位: Miyagi University of Education
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500771/
• 关键词: 運動性高血流; 血管拡張機構; 経壁圧変化; 供給動脈; 自発走運動; 加齢; ラット; ラット骨格筋細動脈; 血管圧縮変形; ラット骨格筋

The purpose of this study was to determine the effects of 10 weeks of voluntary wheel running and aging on the threshold and amplitude of mechanical vasodilation in the feed arteries of rat skeletal muscle. The threshold transmural pressure of the mechanical vasodilation was 0 mmHg in cage control, VR and aged rats. The amplitude of mechanical vasodilation of the feed arteries in VR rats was significantly larger than that in cage control and aged rats (p<0.001). The amplitude of mechanical vasodilation was decreased significantly (p<0.001) following removal of the endothelium by air. These results indicate that the threshold transmural pressure of mechanical vasodilation of the soleus feed arteries was not altered by VR and aging, whereas the amplitude of mechanical vasodilation was increased by VR.

本研究的目的是确定 10 周的自愿轮跑和衰老对大鼠骨骼肌供血动脉机械血管舒张阈值和幅度的影响。笼养大鼠、VR大鼠和老年大鼠机械性血管舒张的阈值透壁压为0mmHg。 VR大鼠供血动脉机械性血管舒张幅度显着大于笼养大鼠和老年大鼠（p<0.001）。通过空气去除内皮后，机械血管舒张的幅度显着降低（p<0.001）。这些结果表明，比目鱼肌供给动脉机械性血管舒张的阈值透壁压并未因VR和衰老而改变，而机械性血管舒张的幅度则因VR而增加。

项目成果

Rapid vasodilation induced by mechanical factores in rat skeletal muscle feed arteries and arterioles.

机械因素诱导大鼠骨骼肌供血动脉和小动脉快速血管舒张。

• 发表时间: 2013
• 期刊: Advances in Exercise and Sports Physiology
• 作者: 高橋正人;吉田誠;伊藤行信;川村公一;南條博;増田弘毅;後藤明輝;Suzuki J;MAEDA Junichi
• 通讯作者: MAEDA Junichi

Effects of voluntary wheel running on mechanical vasodilation of the feed arteries of rat soleus muscle.

随意轮跑对大鼠比目鱼肌供血动脉机械性血管舒张的影响。

• 发表时间: 2013
• 期刊: Advances in Exercise and Sports Physiology
• 作者: MAEDA Junichi;KOMIYA Hideaki;SUZUKI Ishimatsu
• 通讯作者: SUZUKI Ishimatsu

血管拡張を生ずる経緯壁圧変動閾値におよぼす加齢の影響

衰老对引起血管舒张的间壁压力波动阈值的影响

• 发表时间: 2014
• 作者: 前田順一;小宮秀明;鈴木石松
• 通讯作者: 鈴木石松

Regulation and adaptation of oxygen gradient and blood flow in skeletal muscle microcirculation

骨骼肌微循环中氧梯度和血流的调节和适应

• 发表时间: 2013
• 期刊: Advances in Exercise and Sports Physiology
• 作者: 湯川治敏;小林一敏;河村庄造;MAEDA Junichi
• 通讯作者: MAEDA Junichi

Rapid vasodilation induced by mechanical factores in rat skeletal muscle feed arteries and arterioles

机械因素诱导大鼠骨骼肌供血动脉和小动脉快速血管舒张

• 发表时间: 2013
• 期刊: Advances in Exercise and Sports Physiology
• 作者: 吉田誠;南條博;庄永傑;川村公一;後藤明輝;増田弘毅;MAEDA Junichi
• 通讯作者: MAEDA Junichi