Effects of voluntary wheel running and aging on mechanical vasodilation of the feed arteries of rat soles muscle.

本研究的目的是确定10周的自愿轮跑和衰老对大鼠骨骼肌饲料动脉血管机械舒张阈值和幅度的影响。大鼠机械血管舒张阈值为0 mmHg。VR大鼠饲料动脉机械血管舒张幅度明显大于笼子对照组和老龄大鼠（p<0.001）。空气去除内皮后，机械血管舒张幅度明显降低（p<0.001）。这些结果表明，VR和衰老对比目鱼饲料动脉机械血管舒张的阈值压力没有影响，而机械血管舒张的幅度却增加了。

The purpose of this study was to determine the effects of 10 weeks of voluntary wheel running and aging on the threshold and amplitude of mechanical vasodilation in the feed arteries of rat skeletal muscle. The threshold transmural pressure of the mechanical vasodilation was 0 mmHg in cage control, VR and aged rats. The amplitude of mechanical vasodilation of the feed arteries in VR rats was significantly larger than that in cage control and aged rats (p<0.001). The amplitude of mechanical vasodilation was decreased significantly (p<0.001) following removal of the endothelium by air. These results indicate that the threshold transmural pressure of mechanical vasodilation of the soleus feed arteries was not altered by VR and aging, whereas the amplitude of mechanical vasodilation was increased by VR.