Effects of aging and physical activity on regulation of ghrelin system

与年龄相关的生长激素分泌和食物摄入的下降分别被称为衰老的体停息和厌食症。胃饥饿素（Ghrelin）是从人和大鼠胃中分离得到的生长激素促分泌素受体的内源性配体，是一种胃源性28氨基酸肽。当对啮齿类动物和人类进行外围注射时，生长素刺激生长激素的释放和食物摄入。因此，以外周组织分解代谢-合成代谢失衡为代表的衰老过程可能会增加胃饥饿素的利用，以维持细胞功能、身体活动和健康。不幸的是，我无法确定小鼠胃饥饿素合成与年龄有关的下降。而我发现血浆胃饥饿素水平与心血管疾病发病率之间的关系。维持足够的胃饥饿素水平似乎可以预防与生活方式有关的疾病的发生，并改善身体健康。

Age-related declines of growth hormone secretion and food intake have been termed the somatopause and anorexia of aging, respectively. Ghrelin, a stomach-derived 28-amino-acid peptide, was isolated from human and rat stomachs as an endogenous ligand of growth hormone secretagogue receptor. Ghrelin stimulates growth hormone release and food intake when peripherally administered to rodents and humans. Therefore, aging process represented by catabolic-anabolic imbalance in peripheral tissues may increase ghrelin utilization to maintain cell functions, physical activity, and health. Unfortunately I could not identify the age-related decline of ghrelin synthesis in mice. Whereas I found relationship between plasma ghrelin level and incidence of cardiovascular disease. A maintenance of adequate ghrelin level seems to prevent the incidence of lifestyle related disease and to improve physical fitness for health.