A basic study on utilization of ghrelin-induced anabolic effect to improve skeletal muscle metabolism

胃促生长素是一种在胃中产生的多肽，可以刺激摄食和生长激素分泌。我在这里研究了Ghrelin是否改善了肌肉萎缩、代谢综合征和卧床不起。Ghrelin治疗暴露于后肢悬吊导致的肌肉萎缩的小鼠，增加了胰岛素信号(合成代谢功能)，并降低了萎缩相关的E3泛素连接酶的表达(分解功能)。Ghrelin的这些抗萎缩作用是通过间接作用于小鼠骨骼肌实现的。发挥Ghrelin诱导的抗萎缩作用是增加生长激素分泌和摄食量所必需的。Ghrelin治疗能有效预防和改善肌肉萎缩。

Ghrelin, a peptide produced in the stomach, stimulates feeding and growth hormone secretion. I studied here whether ghrelin improved muscle atrophy, metabolic syndrome, and bedridden. Ghrelin treatment in mice exposed to hindlimb suspension-induced muscle atrophy increased insulin signal (anabolic function), and decreased expressions of atrophy-related E3 ubiquitin ligases (catabolic function). These anti-atrophic functions by ghrelin were indirectly effect in mice skeletal muscle. To exert ghrelin-induced anti-atrophic functions was necessary for increases of growth hormone secretion and food intake. Ghrelin treatment was effective for the prevention and improvement of muscle atrophy.