Effect of exercise training on endogenous carbon monoxide exhalation in humans.

在本研究中，我们旨在测量吸烟者和非吸烟者在运动期间和运动后呼出的一氧化碳（CO）。我们可以观察到呼出的一氧化碳随着运动强度的增加而增加，运动后迅速减少。吸烟者的CO呼出量明显大于非吸烟者。我们还试图开发一个原型模型来估计碳氧血红蛋白浓度（COHb）transmittance在血液中使用多波长光源。COHb可以通过原型模型进行连续测量，但是仍然存在与稳定性和分辨率相关的问题。此外，我们还测量了小鼠中产生CO的酶血红素氧合酶-1和-2的表达，发现这些酶在骨骼肌中的表达随着急性运动和力量训练而增加。

In the present study we aimed to measure exhaled carbon monoxide (CO) during and after exercise in smokers and non-smokers. We could observe that exhaled carbon oxide increased relatve to exercise intensity and decreased rapidly after exercise. The amounts of CO exhalation in smokers were significantly larger than those of non-smokers. We also attempted to develop a prototype model to estimate carboxyhemoglobin concentrations (COHb) transcutaneously in the blood using multi-wavelength optical sources. The COHb could be continuously measured by a prototype model, however problems relevant to the stability and resolution still remained. Furthermore, we also measured the expression of heme oxygenase-1 and -2 which are the enzymes producing CO in mice, and found that the expression of these enzymes in the skeletal muscles increased with acute exercise and strength training.