Effect of exercise training on endogenous carbon monoxide exhalation in humans.

运动训练对人体内源性一氧化碳呼出的影响。

• 批准号: 23500779
• 负责人: YASUDA Yoshifumi
• 金额: $ 3.24万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500779/
• 关键词: ガス状伝達物質; 一酸化炭素; 硫化水素; ヘムオキシゲナーゼ; パルスオキシメータ; カーボライザー; 呼気ガス; 一酸化窒素; カルボキシヘモグロビン; heme oxygenase; 運動; トレーニング

In the present study we aimed to measure exhaled carbon monoxide (CO) during and after exercise in smokers and non-smokers. We could observe that exhaled carbon oxide increased relatve to exercise intensity and decreased rapidly after exercise. The amounts of CO exhalation in smokers were significantly larger than those of non-smokers. We also attempted to develop a prototype model to estimate carboxyhemoglobin concentrations (COHb) transcutaneously in the blood using multi-wavelength optical sources. The COHb could be continuously measured by a prototype model, however problems relevant to the stability and resolution still remained. Furthermore, we also measured the expression of heme oxygenase-1 and -2 which are the enzymes producing CO in mice, and found that the expression of these enzymes in the skeletal muscles increased with acute exercise and strength training.

在本研究中，我们的目标是测量吸烟者和非吸烟者在运动期间和运动后呼出的一氧化碳（CO）。我们可以观察到呼出的一氧化碳随着运动强度的增加而增加，运动后迅速减少。吸烟者的CO呼出量明显大于非吸烟者。我们还试图开发一个原型模型来估计碳氧血红蛋白浓度（COHb）transmittance在血液中使用多波长光源。COHb可以通过原型模型进行连续测量，但是仍然存在与稳定性和分辨率相关的问题。此外，我们还测量了小鼠中产生CO的酶血红素氧合酶-1和-2的表达，发现这些酶在骨骼肌中的表达随着急性运动和力量训练而增加。

项目成果

呼気微量ガス

呼出微量气体

• 发表时间: 2012
• 作者: Aoi W;Sakuma K;安田好文
• 通讯作者: 安田好文

Quantitative and convinient measurement of hemodynamics using spatially-resolved near infrared spectroscopy.

使用空间分辨近红外光谱法定量、便捷地测量血流动力学。

• 发表时间: 2013
• 作者: Wagatsuma A;Sakuma K.;M. Ｎｉｗａｙａｍａ
• 通讯作者: M. Ｎｉｗａｙａｍａ

Miniaturized sample preparation needle for human breath analysis in capillary gas chromatography

用于毛细管气相色谱中人体呼吸分析的微型样品制备针

• 发表时间: 2012
• 作者: Y. Saito;K Ueta;S. Fujimura A. Ellwood
• 通讯作者: S. Fujimura A. Ellwood

Effect of ramp bicycle exercise on carbon monoxide exhalation in smokers and non-smokers.

坡道自行车运动对吸烟者和非吸烟者一氧化碳呼出的影响。

• 发表时间: 2011
• 作者: Yasuda Y;Ito T;Miyamura M;Niwayama M.
• 通讯作者: Niwayama M.

Development od an implantable flexible probe for simultaneous near-infrared spectroscopy and electrocorticography.

开发用于同步近红外光谱和皮层电图描记的植入式柔性探针。

• DOI: 10.1109/tbme.2013.2279888
• 发表时间: 2014
• 期刊: IEEE Trans. Biomed. Eng.
• 作者: T. Yamakawa;T. Inoue;Y. He;M. Fujii;M. Suzuki;M. Niwayama
• 通讯作者: M. Niwayama