Effect of exercise training on endogenous carbon monoxide exhalation in humans.

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In the present study we aimed to measure exhaled carbon monoxide (CO) during and after exercise in smokers and non-smokers. We could observe that exhaled carbon oxide increased relatve to exercise intensity and decreased rapidly after exercise. The amounts of CO exhalation in smokers were significantly larger than those of non-smokers. We also attempted to develop a prototype model to estimate carboxyhemoglobin concentrations (COHb) transcutaneously in the blood using multi-wavelength optical sources. The COHb could be continuously measured by a prototype model, however problems relevant to the stability and resolution still remained. Furthermore, we also measured the expression of heme oxygenase-1 and -2 which are the enzymes producing CO in mice, and found that the expression of these enzymes in the skeletal muscles increased with acute exercise and strength training.