Case-control study by the polyhedral approach which aimed at the early detection of depression in young women

旨在早期发现年轻女性抑郁症的多面方法病例对照研究

• 批准号: 23500823
• 负责人: IIDA Tadayuki
• 金额: $ 3.24万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500823/
• 关键词: 抑うつ; 8-OHdG; ストレス; 月経; 若年女性; SDS; 8-OH-dG; Biopyrrin; セロトニン; TRAP-5b; 女性; 抑うつ症状; 月経周期; エストロゲン

This study aimed to clarify the association between depressive symptoms and a marker of DNA damage due to oxidative stress in young females. Since the menstrual cycle may confound or modify the association, depressive symptoms and urinary levels of 8-hydroxy-2' deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (21.6(0.8)) of a Japanese health science university were studied. The menstrual cycle was divided into 3 phases: menstrual (days 1 to 3 after the onset of menses): proliferative (13 to 15): and secretory (24 to 26). The menstrual cycle adjusted 8-OHdG level was significantly higher in those with depressive symptom than those without. The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance in all the menstrual cycle (0.73-0.81, all p<0.05). These results indicated the existence of oxidative stress in subjects with depressive symptom independent of the menstrual cycle.

本研究旨在阐明年轻女性抑郁症状与氧化应激导致的DNA损伤标志物之间的关系。由于月经周期可能会混淆或改变这种关联，因此在每个月经期评估抑郁症状和8-羟基-2 '脱氧鸟苷（8-OHdG）的尿液水平。共有57名女性四年级学生（21.6（0.8））的日本保健科学大学进行了研究。月经周期分为3个阶段：月经期（月经开始后1 - 3天）、增殖期（13 - 15天）和分泌期（24 - 26天）。有抑郁症状者月经周期调整后8-OHdG水平显著高于无抑郁症状者。ROC曲线分析显示，尿8-OHdG水平在整个月经周期中具有相当高的区分性能（0.73-0.81，均p<0.05）。这些结果表明，氧化应激的存在与月经周期无关的抑郁症状的主题。

项目成果

月経周期別にみた若年女性における抑うつ症状の有無による尿中8-OH-dG量の比較

根据月经周期年轻女性是否存在抑郁症状比较尿 8-OH-dG 水平

• 作者: 飯田忠行;伊藤康弘;井上 顕;石川浩章;寺平良治;近村千穂;八谷 寛
• 通讯作者: 八谷 寛

中高年女性における体力指標が大腿骨骨密度および下肢筋肉量・脂肪率に及ぼす影響の縦断的研究

体质指标对中老年女性股骨骨密度及下肢肌质量/脂肪率影响的纵向研究

• 作者: 飯田忠行;近村千穂;池田ひろみ;青井聡美;塩川満久;石崎文子
• 通讯作者: 石崎文子

加齢に伴う骨密度・骨代謝の変化-身体的特徴や骨代謝マーカーが骨密度減少に及ぼす影響-.

与衰老相关的骨密度和骨代谢的变化 - 身体特征和骨代谢标志物对骨密度损失的影响。

• 发表时间: 2012
• 期刊: 診療と新薬
• 作者: 飯田忠行;石崎文子,池田ひろみ,青井聡美,近村千穂,塩川満久,原田俊英
• 通讯作者: 石崎文子,池田ひろみ,青井聡美,近村千穂,塩川満久,原田俊英

Seasons for the increase in suicides in Japan.

日本自杀率上升的季节。

• 发表时间: 2012
• 期刊: International Medical J
• 作者: Inoue K;Fukunaga T;Fujita Y;Iida T;Abe S;Ono Y
• 通讯作者: Ono Y

Usefulness of the touch panel-type dementia assessment scale (TDAS) and evaluation of correlation between hemoglobin A1c and TDAS in middle-Aged and older women

触摸屏式痴呆评估量表（TDAS）在中老年女性中的实用性及血红蛋白A1c与TDAS的相关性评价

• 发表时间: 2013
• 期刊: Hiroshima J. Med. Sci
• 作者: Ikeda H;Ishizaki F;Shiokawa M;Aoi S;Iida T (他3名)
• 通讯作者: Iida T (他3名)