Case-control study by the polyhedral approach which aimed at the early detection of depression in young women

本研究旨在阐明年轻女性抑郁症状与氧化应激引起的DNA损伤标志物之间的关系。由于月经周期可能混淆或改变这种关联，因此在每个月经期评估抑郁症状和尿中8-羟基-2'脱氧鸟苷（8-OHdG）的水平。本研究以日本某健康科学大学四年级女学生57名（21.6(0.8)）为研究对象。月经周期分为3个阶段：月经期（月经开始后第1 ~ 3天）、增殖期（13 ~ 15天）和分泌期（24 ~ 26天）。有抑郁症状者月经周期调整后的8-OHdG水平显著高于无抑郁症状者。ROC曲线分析显示，尿8-OHdG水平在整个月经周期具有较高的判别性能（0.73-0.81,p<0.05）。这些结果表明氧化应激的存在与月经周期无关。

This study aimed to clarify the association between depressive symptoms and a marker of DNA damage due to oxidative stress in young females. Since the menstrual cycle may confound or modify the association, depressive symptoms and urinary levels of 8-hydroxy-2' deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (21.6(0.8)) of a Japanese health science university were studied. The menstrual cycle was divided into 3 phases: menstrual (days 1 to 3 after the onset of menses): proliferative (13 to 15): and secretory (24 to 26). The menstrual cycle adjusted 8-OHdG level was significantly higher in those with depressive symptom than those without. The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance in all the menstrual cycle (0.73-0.81, all p<0.05). These results indicated the existence of oxidative stress in subjects with depressive symptom independent of the menstrual cycle.