Usefulness of central arterial presure response to dynamic exercise for the assessment of vascular endotherial function

中心动脉压对动态运动的反应对于评估血管内皮功能的有用性

• 批准号: 23500840
• 负责人: MIYAI Nobuyuki
• 金额: $ 3.08万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500840/
• 关键词: 運動負荷試験; 中心動脈圧波; 動脈伸展性; 血管内皮機能; 動脈硬化; 反射指標; 反射指数

In this study, we have demonstrated that the exaggerated responses of central arterial pressure and wave reflection markers during dynamic exercise are related to a state of structural and functional impairments of the vasculature in the early stages of hypertension. These results suggest that subclinical atherosclerosis may have a greater influence on vascular reactivity than on basal tone and hence could potentially be identified by an abnormal response of central arterial pressure to exercise even before clinical manifestation of atherosclerosis. In addition, an amplified wave reflection from periphery due to the vascular alterations, such as increased arterial stiffness and endothelial dysfunction, induces greater central aortic pressure and leads to the increase in overall left ventricular afterload. Thus, the central arterial pressure response to exercise may also be useful as an evaluation of hypertension-related risks of cardiovascular complications.

在这项研究中，我们已经证明，在动态运动过程中的中央动脉压和波反射标记物的夸张的反应有关的高血压的早期阶段的血管结构和功能障碍的状态。这些结果表明，亚临床动脉粥样硬化对血管反应性的影响可能大于对基础张力的影响，因此，即使在动脉粥样硬化临床表现之前，也可能通过中心动脉压对运动的异常反应来识别。此外，由于血管改变（如动脉僵硬度增加和内皮功能障碍）引起的外周波反射放大，诱导更大的中心主动脉压，并导致总体左心室后负荷增加。因此，中心动脉压对运动的反应也可能是有用的高血压相关的心血管并发症的风险评估。

项目成果

Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors

• DOI: 10.1038/hr.2012.215
• 发表时间: 2013-06-01
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Miyai, Nobuyuki;Shiozaki, Maki;Arita, Mikio
• 通讯作者: Arita, Mikio

運動負荷に伴う中心動脈圧波の反射波成分の変化と左室壁肥厚との関連

中心动脉压力波反射波成分变化与运动负荷引起的左心室壁增厚的关系

• 发表时间: 2014
• 作者: 宮井信行;塩崎万起;寺田和史;冨田耕太郎;内川友起子;内海みよ子;服部園美;森岡郁晴;有田幹雄;宮下和久
• 通讯作者: 宮下和久

Mean arterial pressure during submaximal exercise is associated with makers of subclinical atherosclerosis in prehypertension

次最大运动期间的平均动脉压与高血压前期亚临床动脉粥样硬化的发生有关

• 发表时间: 2014
• 作者: Miyai N;Shiozaki M;Uchikawa Y;Terada K;Tomida K;Utsumi M;Hattori S;Miyashita K;Arita M
• 通讯作者: Arita M

運動負荷試験による血圧変化に及ぼす動脈伸展性の低下の影響

动脉扩张性下降对运动负荷测试引起的血压变化的影响

• 发表时间: 2012
• 作者: 宮井信行;塩崎万起;内海みよ子;内川友起子;福元仁;森岡郁晴;有田幹雄;武田眞太郎;宮下和久
• 通讯作者: 宮下和久

Central blood pressure response to exercise as an evaluation of left ventricular afterload in early stages of hypertension

运动中枢血压反应作为高血压早期左心室后负荷的评估

• 发表时间: 2012
• 作者: Miyai N;Shiozaki M;Kinjo Y;Uchikawa Y;Fukumoto J;Terada K;Tomida K;Miyashita K;Arita M
• 通讯作者: Arita M