Exploration of AhR activity-inducing staple food components and their preventive effects against colorectal cancer

点击翻译按钮获取中文摘要

To characterize aryl hydrocarbon receptor (AhR)-activating substances in staple foods, the effects of the respective food extracts on AhR were studied. Among the extracts of grains and vegetables, those of rice, broccoli, and spinach markedly induced AhR activity. From active fractions of the rice extract, six compounds, including sinapoyl glycoside, were isolated. Chromatographic separation of an active fraction of the broccoli extract yielded eleven compounds, of which neoascorbigen and sinapoyl glycosides induced AhR activity. Thus, new natural AhR ligand candidates were characterized.