Discovery of a new antitumor drug targeting the tumor-stromal cell interactions

为了创造一种针对肿瘤细胞和肿瘤组织中周围基质细胞之间相互作用的新的抗肿瘤药物，我们开发了两种细胞的共培养系统，并寻找调节这种相互作用的化合物。因此，我们从放线菌的发酵液中分离出一种新的化合物--干预素。当与相应器官来源的基质细胞共培养时，Intervenolin对人胃和结直肠癌细胞系的生长抑制作用比单独培养的癌细胞更强。Intervenolin在体内对人胃和结直肠癌细胞的异种移植模型显示出抗肿瘤作用。

For creation of a new antitumor drug targeting the interactions between tumor cells and the surrounding stromal cells in tumor tissues, we have developed coculture systems of both cells and searched for compounds that modulate the interactions. As a result, we have isolated a new compound, intervenolin, from the culture broth of actinomyces. Intervenolin inhibits the growth of human gastric and colorectal cancer cell lines when cocultured with the respective organ-derived stromal cells more strongly than that of the cancer cells cultured alone. Intervenolin shows antitumor effects against xenograft models of human gastric and colorectal cancer cells in vivo.