Ecotoxicogenomic Studies on Fluoroquinolones Using Nematode Caenorhabditis elegans.

研究左氧氟沙星（LVFX）和托舒沙星（TFLX）等氟喹诺酮类药物对秀丽隐杆线虫（C. elegans）的环境和生物学效应，并与已有喹诺酮类药物萘啶酸（NA）进行比较。两种氟喹诺酮类药物浓度低于NA时对秀丽隐杆线虫的繁殖力和繁殖能力有影响。此外，通过秀丽隐杆线虫DNA芯片分析，LVFX或TFLX暴露可显著下调秀丽隐杆线虫的8个基因，包括mlc-3、cmd-1、col-108和col-139。本研究结果表明，氟喹诺酮类药物可引起秀丽隐杆线虫的多种生物学缺陷，这些影响可能与氟有关。

To investigate environmental and biological effects of fluoroquinolones such as Levofloxacin (LVFX) and Tosufloxacin (TFLX) on the nematode Caenorhabditis elegans (C. elegans) as a model organism and compared it with one of the old quinolones, nalidixic acid (NA). Two fluoroquinolones affected the fecundity and reproduction of C.elegans with lower concentration than NA. In addition, as a result of C. elegans DNA microarray analysis, LVFX or TFLX exposure down-regulated 8 genes in C. elegans including mlc-3, cmd-1, col-108 and col-139, significantly. The findings of the present study demonstrate that fluoroquinolones could cause multiple biological defects to C. elegans and these effects may be relevant to fluorine.